ClusterFree
The world's most painful condition demands urgent action. Help us accelerate access to effective treatments for cluster headaches.
About cluster headache
Cluster headache ("suicide headache") is often considered the most painful medical condition. Patients rate it as significantly more painful than childbirth, kidney stones, gunshot wounds, and bone fractures. Standard painkillers don't help.
Even in wealthy nations with advanced healthcare, hundreds of thousands still experience torture-like suffering every year. About 50% of all patients have contemplated suicide. At the same time, global funding for cluster headache is virtually nonexistent. This crisis cannot go on any longer.
Effective treatments exist
Several treatments have shown remarkable effectiveness against cluster headache, but an alarming fraction of patients struggle to access them.
High-flow oxygen can abort attacks within minutes and is officially recommended by major medical guidelines. Yet even this safe, legal treatment remains difficult for many patients to access due to prescription barriers, insurance gaps, and lack of awareness among doctors.
Psychedelics of the indoleamine family (including psilocybin, LSD, DMT, and 5-MeO-DALT) have shown some of the most impressive results, with 70–80% of surveyed users reporting significant relief. Often, low, sub-hallucinogenic doses are sufficient to prevent entire clusters or stop attacks acutely, with minimal side effects. Similarly, the non-hallucinogenic compound BOL-148 (a derivative of LSD) has shown remarkable efficacy in early research, yet it remains unavailable due to a lack of funding for larger trials.
Given the severity of the pain, failing to make these treatments accessible is analogous to refusing anesthesia to patients during surgery. This is absolutely unacceptable.
We need your help to accelerate access to effective treatments.
Donors
Tawsif Ahmed To the fundraiser: End of Year Fundraiser 20251Take invisible suffering seriously so you can have your invisible suffering taken seriously when you have it!!
Daniel Phillips To the fundraiser: End of Year Fundraiser 20251Possibly the most important and effective suffering-reduction intervention available to humanity right now.
Christoph Ströck To the fundraiser: End of Year Fundraiser 20251Bodhisattvic energy flowing toward purification and clarity, right here, right now.
Thijs Jacobs To the fundraiser: End of Year Fundraiser 20251Very important cause! Happy to donate my End of Year donations to them.
Camille Berger To the fundraiser: End of Year Fundraiser 20251This a common, yet easy-to-solve moral tragedy.
Oleksii Bykhun To the fundraiser: End of Year Fundraiser 20251Great team working on important problem!