Very important cause! Happy to donate my End of Year donations to them.

Impressive plans, totaly worth my end of year donation.

The world's most painful condition demands urgent action. Help us accelerate access to effective treatments for cluster headaches.

**About cluster headache**

Cluster headache ("suicide headache") is often considered the most painful medical condition. Patients [rate it](https://doi.org/10.1111/head.14021) as significantly more painful than childbirth, kidney stones, gunshot wounds, and bone fractures. Standard painkillers don't help.

Even in wealthy nations with advanced healthcare, **hundreds of thousands** still experience torture-like suffering every year. About 50% of all patients have contemplated suicide. At the same time, global funding for cluster headache is virtually nonexistent. **This crisis cannot go on any longer.**

**Psychedelics save lives**

Psychedelics like psilocybin, LSD, and DMT have shown promise in treating cluster headache pain, in some cases with 70–80% of surveyed users reporting significant relief. Some patients even achieve complete remission.

Often, low, sub-hallucinogenic doses are more than enough to prevent clusters or stop attacks acutely. Patients could self-medicate safely and with minimal side effects.

However, only a tiny minority of patients have access to these life-saving treatments. Given the severity of the pain, the situation is analogous to refusing anesthesia to patients during surgery. **This is absolutely unacceptable.**

We need your help to accelerate access to effective treatments.

[Learn more](https://clusterfree.org/learn)

ClusterFree

Working on improving the lives of farmed fish, a neglected problem with enormous scale, in the Philippines and Vietnam

Around **4,000 fish are killed in industrial farms every second** and 73-180 billion fish are being farmed at any given time. There’s an [abundence of evidence](https://www.canva.com/link?target=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Farticles%2FPMC9100576%2F&design=DAGj7Qj3OhY&utl=h29e626b61a&accessRole=owner&linkSource=document) that fish are sentient and experience pain, meaning that farmed fish are suffering at an unfathomable scale, particularly in Asia which farms 90% of the world’s farmed fish. This is [twice the number of fish](https://https://animalcharityevaluators.org/charity-reviews/causes-we-consider/#farmed-animals) as there are land-based farmed animals worldwide. 

Despite this enormous scale of suffering, **farmed fish welfare receives virtually no attention or resources**—especially in Asia where conditions are often severe and regulations minimal.

**Scale Welfare is working to find solutions that actually work.** We're conducting rigorous field studies in the Philippines and Vietnam to test multiple intervention approaches and identify the most scalable and cost-effective ways to improve farmed fish welfare.

Scale Welfare was **incubated through Ambitious Impact's Charity Incubation Program**, which helped us develop our evidence-based approach to this neglected cause area.

Our research will determine which interventions- whether farmer training, improved systems, or policy changes—can create the greatest impact. **Once we identify what works, we'll pilot and scale these solutions** to improve conditions for millions, potentially billions, of farmed fish.

**Your donation helps us:** conduct the research needed to identify effective solutions, support field studies testing different approaches, and build the groundwork for potentially scaling welfare improvements.

Scale Welfare

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