Satb2 Gene Foundation Inc

The SATB2 Gene Foundation works to enrich the lives of individuals with SATB2-associated syndrome (SAS), including those diagnosed with the condition and their families through support, research and education by:

• Providing support to families.
• Supporting research in a wide range of issues related toSATB2-associated syndrome.
• Raising awareness about the characteristics of SATB2-associated syndrome.

Individuals with mutations or deletions in the SATB2 gene, which plays a crucial role in development, particularly in the brain, bones and cranial structures, have SAS. They are generally very kind and happy, with the most beautiful smiles you may have ever seen. However, this syndrome significantly affects all areas of development, including speech (absent speech in most or significantly delayed/affected speech), cognition (intellectual disability), fine motor skills, and gross motor skills. Individuals with SAS have palatal abnormalities, including cleft palate and high arched palate, as well as dental issues, including missing adult teeth and/or oversized front teeth. Additional medical issues include sleep issues, low bone density, and as the children get older, significant behavioral issues develop.