Your generous donation helps us tackle one of the most urgent health crises of our time. We have ambitious plans, and we rely on donations to make these plans a reality.

ClusterFree launched only a few months ago, but we are excited about the progress we've made so far with a small team and a shoestring budget. Among others, we:

- Launched our [open letters](https://clusterfree.org/global), which have been signed by people like [Prof. Peter Singer](https://www.petersinger.info/), [Dr. Christopher Gottschalk](https://medicine.yale.edu/profile/chris-gottschalk/), [Scott Alexander](https://www.astralcodexten.com/p/open-thread-409), and many more.
- Started an official collaboration with [Clusterbusters](https://clusterbusters.org).
- Gained the support of a member of a US state legislature.
- Started conversations with CH advocates in multiple countries (most recently India, Denmark, and New Zealand).
- Are engaging with entrepreneurs and philanthropists interested in bringing [DMT](https://forum.effectivealtruism.org/posts/x8P8EGnujSZm6fyMH/emerging-evidence-on-treating-cluster-headaches-with-dmt) to market.
- Developed a preliminary idea for a new, legal abortive treatment that could be highly effective (potentially also for migraines).
- Started developing phenomenology-based, patient-centric surveys to test various hypothesis for the underlying mechanism of action that psychedelics exert on this condition.

Donations at this early stage would help us hire a second teammate to accelerate our efforts.

We believe ClusterFree is a great donation opportunity for people who care about relieving the most intense human suffering today. Cluster headaches represent a major health crisis even in developing countries, and we are far from having effective treatments widely available. Help us change that. 

--

"Your cluster headache work is superb and admirable - I signed with pleasure." - Robert Lawrence Kuhn

"I appreciate your work on this important issue." - Prof. Peter Singer

"clusterfree.org is really well put together, with the most important info easily accessed and well focused IMO - a great, appreciated resource!" - Clusterbusters forum user

End of Year Fundraiser 2025

The world's most painful condition demands urgent action. Help us accelerate access to effective treatments for cluster headaches.

**About cluster headache**

Cluster headache ("suicide headache") is often considered the most painful medical condition. Patients [rate it](https://doi.org/10.1111/head.14021) as significantly more painful than childbirth, kidney stones, gunshot wounds, and bone fractures. Standard painkillers don't help.

Even in wealthy nations with advanced healthcare, **hundreds of thousands** still experience torture-like suffering every year. About 50% of all patients have contemplated suicide. At the same time, global funding for cluster headache is virtually nonexistent. **This crisis cannot go on any longer.**

**Psychedelics save lives**

Psychedelics like psilocybin, LSD, and DMT have shown promise in treating cluster headache pain, in some cases with 70–80% of surveyed users reporting significant relief. Some patients even achieve complete remission.

Often, low, sub-hallucinogenic doses are more than enough to prevent clusters or stop attacks acutely. Patients could self-medicate safely and with minimal side effects.

However, only a tiny minority of patients have access to these life-saving treatments. Given the severity of the pain, the situation is analogous to refusing anesthesia to patients during surgery. **This is absolutely unacceptable.**

We need your help to accelerate access to effective treatments.

[Learn more](https://clusterfree.org/learn)

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