Possibly the most important and effective suffering-reduction intervention available to humanity right now.

Your generous donation helps us tackle one of the most urgent health crises of our time. We have ambitious plans, and we rely on donations to make these plans a reality.

ClusterFree launched only a few months ago, but we are excited about the progress we've made so far with a small team and a shoestring budget. Among others, we:

- Launched our [open letters](https://clusterfree.org/global), which have been signed by people like [Prof. Peter Singer](https://www.petersinger.info/), [Dr. Christopher Gottschalk](https://medicine.yale.edu/profile/chris-gottschalk/), [Scott Alexander](https://www.astralcodexten.com/p/open-thread-409), and many more.
- Started an official collaboration with [Clusterbusters](https://clusterbusters.org).
- Gained the support of a member of a US state legislature.
- Started conversations with CH advocates in multiple countries (most recently India, Denmark, and New Zealand).
- Are engaging with entrepreneurs and philanthropists interested in bringing [DMT](https://forum.effectivealtruism.org/posts/x8P8EGnujSZm6fyMH/emerging-evidence-on-treating-cluster-headaches-with-dmt) to market.
- Developed a preliminary idea for a new, legal abortive treatment that could be highly effective (potentially also for migraines).
- Started developing phenomenology-based, patient-centric surveys to test various hypothesis for the underlying mechanism of action that psychedelics exert on this condition.

Donations at this early stage would help us hire a second teammate to accelerate our efforts.

We believe ClusterFree is a great donation opportunity for people who care about relieving the most intense human suffering today. Cluster headaches represent a major health crisis even in developing countries, and we are far from having effective treatments widely available. Help us change that. 

--

"Your cluster headache work is superb and admirable - I signed with pleasure." - Robert Lawrence Kuhn

"I appreciate your work on this important issue." - Prof. Peter Singer

"clusterfree.org is really well put together, with the most important info easily accessed and well focused IMO - a great, appreciated resource!" - Clusterbusters forum user

End of Year Fundraiser 2025

The world's most painful condition demands urgent action. Help us accelerate access to effective treatments for cluster headaches.

**About cluster headache**

Cluster headache ("suicide headache") is often considered the most painful medical condition. Patients [rate it](https://doi.org/10.1111/head.14021) as significantly more painful than childbirth, kidney stones, gunshot wounds, and bone fractures. Standard painkillers don't help.

Even in wealthy nations with advanced healthcare, **hundreds of thousands** still experience torture-like suffering every year. About 50% of all patients have contemplated suicide. At the same time, global funding for cluster headache is virtually nonexistent. **This crisis cannot go on any longer.**

**Psychedelics save lives**

Psychedelics like psilocybin, LSD, and DMT have shown promise in treating cluster headache pain, in some cases with 70–80% of surveyed users reporting significant relief. Some patients even achieve complete remission.

Often, low, sub-hallucinogenic doses are more than enough to prevent clusters or stop attacks acutely. Patients could self-medicate safely and with minimal side effects.

However, only a tiny minority of patients have access to these life-saving treatments. Given the severity of the pain, the situation is analogous to refusing anesthesia to patients during surgery. **This is absolutely unacceptable.**

We need your help to accelerate access to effective treatments.

[Learn more](https://clusterfree.org/learn)

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