The Multidisciplinary Association for Psychedelic Studies supports psychedelic and cannabis research, education and policy reform.

Founded in 1986, the Multidisciplinary Association for Psychedelic Studies (MAPS) is a visionary 501(c)(3) non-profit organization ushering the safe and ethical use of psychedelics as tools for healing and growth on individual, familial, societal, and planetary levels.

MAPS’ top priority is ethically introducing global access to MDMA-assisted therapy as a treatment for posttraumatic stress disorder (PTSD) through regulatory approvals and training certification for therapy providers, as well as public education, policy reform, and building community support networks.

How Your Donation Will Help

While the MDMA drug development program is the main priority of MAPS, the organization's programs include research into other psychedelic compounds and provide critical resources for researchers around the world interested in studying psychedelics. These resources include assistance with protocol development and regulatory guidance, in addition to providing study drug and training for investigators. As part of its commitment to open science and open praxis, MAPS publishes its research protocols, treatment manual for MDMA-assisted therapy for PTSD, published articles, and investigator's brochure on its website for free download, and actively collaborates with third-party researchers and institutions. Researchers and institutions around the world are building on the body of research that MAPS has produced.

MAPS operates a global network of intersectional education and research programs focused on the careful study of the risks and benefits of psychedelics. The education programs include: harm reduction and peer support through the Zendo Project; policy and advocacy efforts focused on community organizing and reducing barriers to research; a conflict resolution initiative for peace-building; and an active fiscal sponsorship program for fledgling mission-aligned organizations. MAPS also produces myriad educational materials, training workshops, and conferences, both physical and virtual. MAPS builds its global community of support through: outreach at events worldwide; a robust social media presence; and interviews and publications in various global media outlets. All of this work is supported by MAPS’ general operating fund. 

MAPS aims to transcend geopolitical and social boundaries and intentionally cultivates interactions with thought leaders in a broad range of interest areas and outlets that demonstrate the broad applications of the healing potential of psychedelics, and to proactively build trust and common ground with those most likely to have resistance to psychedelics.  

A Tipping Point for Psychedelic Medicine

MDMA-assisted therapy is poised to be a true breakthrough for psychedelic medicine and is the first psychedelic therapy to enter a Phase 3 clinical trial. This trial recently cleared a critical interim evaluation, with analysis confirming a 90% or greater likelihood that the final results will show significant effectiveness in treating PTSD. Achieving FDA approval for this treatment could be the tipping point to shifting psychedelics into the medical mainstream. This shift has the potential to unlock previously unavailable resources for the investigation of psychedelic-assisted treatments applied to our most critical mental health challenges: trauma, depression, addiction, anxiety, and more.

When administered in a clinical setting with trained therapy providers, MDMA has proven to be a powerful adjunct to therapy, which assists individuals in processing traumatic experiences in a deep and profound manner, leading to the alleviation of suffering. Clinical research indicates that MDMA may catalyze therapeutic processing by allowing participants to stay emotionally engaged when revisiting traumatic experiences, without feeling overwhelmed by anxiety or other painful emotions.

FDA approval of MDMA-assisted therapy for PTSD could help millions of people who are suffering from trauma. A long-term follow-up study published in June 2020 demonstrated that 67% of the study volunteers (N=91) who had PTSD for an average duration of 17.8 years were still in remission and no longer qualified for a PTSD diagnosis at least 12-months following the completion of their treatment. 

While MAPS is the engine that powers this research, passionate supporters are the fuel that feeds our fire. We are inspired to press on towards the finish line of this 35-year marathon.

If you have any questions, please email us at giving@maps.org.

MAPS

The Markup is a nonprofit newsroom that investigates how powerful institutions are using technology to change our society.

As a nonprofit newsroom, our journalism exists to serve the public. And that’s why we have embraced a Show Your Work philosophy. Whenever possible, we will publish the underlying datasets and code that we use in our investigations, as well as a detailed methodology describing the data, its provenance and the statistical techniques used in our analysis. We invite academics, journalists, policymakers, consumer activists, and community organizers to engage with our findings—after all, this is for you.

We also want our stories to reach you where you are. That means we will publish our stories on our own site and also through distribution partnerships with other media.  And because we know many different types of audiences—including those we don’t know about!—will be interested in our work, we encourage you to freely republish our work under the terms of our Creative Commons license. 

The Markup

We want to make life better for wild animals.

We are dedicated to finding evidence-backed ways to improve the lives of animals in the wild.

We depend on individual donors to help us make life better for wild animals. To a small nonprofit working hard on a big problem, your support is more crucial now than ever!

Wild Animal Initiative

The Kodi Foundation is the non-profit organization that oversees and operates the Kodi media centre project. 

The Kodi Foundation handles all financial items as well as IP and trademark related issues and enquiries. Generally it covers all of the back-office and administrative aspects of the project, as a rule of thumb it handles everything but the code.

Kodi Foundation

Support impactful organizations solving the world’s biggest challenges with cutting edge research and policy.

## The Founders Pledge Perspective

Science and technology have created amazing advances in human civilization, from agriculture to industry and beyond. Yet they have also created new challenges, both foreseen and unforeseen: the threat of engineered pandemics more deadly than any naturally occuring virus, the risk of artificial intelligence unaligned with conventional human values, the mental health implications of lives lived online, and others we may not yet recognize.

To address these challenges, improve the lives of people today, and protect future generations from natural and man-made risks, Founders Pledge has identified a short-list of charities working at the cutting edge of global risk response and human wellbeing. These organizations convene stakeholders, conduct research, and advocate for better national and global policies based on the best available evidence.

By giving to the Founders Pledge Science and Technology Index, you can spread your donation across several highly-impactful and neglected organisations working to answer big questions and create solutions to problems that affect us all. By pooling your donations, this Index fund allows you to make larger grants and thereby maximize your impact.

## Our Approach to Grantmaking

When evaluating potential grants, we consider several key points:

- **Counterfactual impact**. Our grants are designed to create a meaningful outcome that would not otherwise have happened. In particular, we aim to make grants that otherwise wouldn’t have been made, rather than those which just take the place of other philanthropists’ donations. This means that you can rely on the Funds to create meaningful, real change, rather than just maintaining the status quo.
- **The grant’s potential outcomes**. We focus on outcomes (e.g. how many lives were saved), rather than outputs (e.g. how many products were delivered). We review all the available evidence and take into account cost-effectiveness to assess whether the grant money could produce more good if donated elsewhere.
- **The organization’s funding gap**. Not all organizations are set up to scale up their programming and many can’t productively absorb large amounts of unsolicited funding. We evaluate all potential grantees’ capacity for growth and consider how much money they could put to good use.
- **Organizational strength**. Particularly with unrestricted funding, it’s important to have trust in the leadership and capacity of the organizations we support. We look at their track record of success and their transparency about failures as well as successes, and we only support those organizations which are exceptionally well run. We also look for organizations that demonstrate a strong commitment to measuring outcomes and evaluating the impact of their programs.

Science & Technology Index

801 Labs is a Salt Lake City based hackerspace created by local information security enthusiasts.


What is 801 Labs?

801 Labs is a Salt Lake City based hackerspace created by local information technology, electronics, and information security enthusiasts. 801 Labs is a physical space designed to be a center for peer learning and knowledge sharing in the form of workshops, presentations, and lectures. We also offer regular activities to the community, where people can gather to work on their own projects, exchange ideas, and learn from each other. Since 801 Labs is intended to be a shared community resource, almost all of our events are free and open to the public.

What will I learn at 801 Labs?

801 Labs runs a wide variety of classes that cover topics ranging from designing and building electronics, to information security, to programming, to 3D printing and 3D modeling, and more. Since we are a community run organization, our class offerings are based on what members of the local community are proficient in and willing to teach. The best way to find out exactly what you can learn is to check out our upcoming events. If you’ve got something you want to teach or would like to learn about, you can check out the get involved section and let us know you’d like to teach a class, or to let us know there is interest in a topic so that we can try to organize a class to cover that topic.


801 Labs

Universal access to all knowledge. Non-profit library of millions of free books, movies, software, music, websites, and more.

The Internet Archive, a 501(c)(3) non-profit, is building a digital library of Internet sites and other cultural artifacts in digital form. Like a paper library, we provide free access to researchers, historians, scholars, the print disabled, and the general public. Our mission is to provide Universal Access to All Knowledge.

We began in 1996 by archiving the Internet itself, a medium that was just beginning to grow in use. Like newspapers, the content published on the web was ephemeral - but unlike newspapers, no one was saving it. Today we have 20+ years of web history accessible through the Wayback Machine and we work with 625+ library and other partners through our Archive-It program to identify important web pages.

Internet Archive

An organization focused on science and technology. It received its nonprofit status in 2020.

OSSEM HOLON

Open Source Security Engineering & Modification Group

We are made up of engineers, computer scientists, hackers, tinkerers, and makers.

We strive to create an environment where people can learn, teach, and play in the technological realm.

Everyone is encouraged to come and share.

We are entirely user-powered, which means we want you to participate in the community, so if you have a subject you would like to talk about, Present, or show & tell, we look forward to it!

Ossem Holon

Black Sisters in STEM is building the LinkedIn for Black College Women in STEM.

Black Sisters in STEM is building the largest talent marketplace of Black college women in STEM across the US and Black diaspora. 

Black women constitute only 2 percent of STEM jobs. A statistic that has been stagnant since 2018. Black Women represent the largest unserved market and largest disruptive force in business. Black women struggle at every stage of the STEM pipeline. It’s not due to lack of desire, or capacity, it’s to lack of support.

We have built an ecosystem composed of ~4k women in 16 countries, with 12 of those countries being in Africa. Black SiS is already working with companies such as Google, Goldman Sachs, Coursera, Bank of America, BCG, etc. We have been recognized by the UN, Nonprofit HR, Voodle, etc.

By actively engaging historically marginalized populations organizations can access untapped talent to meet evolving workforce needs and reimagine work itself. 





Black Sisters in STEM (Black SiS)

FAB provides funding, promotion, education and credibility to creators working at the intersection of blockchain and creativity.

Foundation For Art And Blockchain

Advancing excellence in education, research, exhibition and conservation of desert plants of the world.

In 1939, a small group of passionate local citizens saw the need to conserve the beautiful desert environment. One was Swedish botanist Gustaf Starck, who found like-minded residents by posting a sign that read “Save the Desert.”

With the support of social influencers of the time such as Gertrude Divine Webster, the Garden’s presence grew. Nearly eight decades later, thanks to leadership and investments from many individuals, Desert Botanical Garden has blossomed from a dream into a living museum.

The Garden’s vision is to be the premier center in the world for the exhibition, research and conservation of desert plants. The Garden strives to be an indispensable resource for learning about cactus, agave and other desert plants of the Sonoran Desert and the world. Every element of the Garden reflects excellence, beauty and inspiration to transform the guest experience into one of discovery. The Garden is here to help everyone enjoy the beauty of the desert and to help them care about protecting and sustaining the natural world for the benefit of future generations.

Desert Botanical Garden

Originally founded in 1892, The Stanford Daily is the independent, student-run newspaper of Stanford University.

The Corporation
The Stanford Daily newspaper is the primary holding of The Stanford Daily Publishing Corporation. Founded in 1973, The Stanford Daily Publishing Corporation operates as a California non-profit corporation headed by the paper’s editor-in-chief and business manager.

Publishing
The Stanford Daily publishes Monday through Friday during the academic year and maintains a circulation of 4,000 to more than 200 locations on and around the main Stanford main campus. The Daily publishes several special issues every year, including a New Student Orientation issue, a Big Game issue and a Commencement issue.

History of The Daily
The Stanford Daily is the independent, student-run newspaper of Stanford University. The Daily was originally founded as a small pamphlet known as The Daily Palo Alto in 1892 and has been a campus fixture ever since. The Daily strives to serve the Stanford community with relevant, unbiased journalism and provides its editorial, tech and business staffs with unparalleled educational opportunities.

The Daily became independent of Stanford University in 1973 after a years-long clash with the administration spurred in part by disagreements over The Daily’s coverage of anti-Vietnam War protests. In particular, a strongly worded 1970 op-ed in the newspaper entitled “Snitches and Oppression,” penned by Diarmuid McGuire M.A. ’73, drew concerns from University administrators that the school might be held liable for any violence incited by the article. Independence for The Daily was thus a logical conclusion for both sides: The Daily’s disentanglement from the University would make it impossible for the University to attempt to influence reporting through financial withholding or other means, and the University’s disentanglement from The Daily would release it of any potential liability for content published in the newspaper. Thus, in 1973, The Stanford Daily Publishing Corporation was incorporated in Santa Clara County as a 501(c)(3) nonprofit organization.

Independence wasn’t the only consequence of The Daily’s coverage of campus antiwar protests; the publication also drew national attention when it sued James Zurcher, the chief of the Palo Alto Police Department, following a surprise search of The Daily’s offices for photographic evidence of protestors that the student-journalists and legal counsel deemed to be in violation of the First and Fourth Amendments. After a district court and court of appeals ruled in favor of The Daily, the case, Zurcher v. Stanford Daily, was brought to the Supreme Court of the United States in 1978, with the nation’s highest court ruling 5-3 in favor of Zurcher. The ensuing outcry among journalists and the public led to Congress’s passage of the Privacy Protection Act of 1980, which established the requirement of a subpoena to search newsrooms for unpublished materials.

With the launch of its website in 1995, The Daily became one of the first college newspapers publishing on the Internet. The site is live and continuously updated throughout the year. It features content from the print edition, along with special Web-only content often including live blogs of sporting events and major campus events.

The Daily moved out of its old offices in the Storke Publications Building to its new home at the Lorry I. Lokey Stanford Daily Building in 2007, thanks to the generosity of Lorry I. Lokey ’49 and hundreds of other benefactors, which would not have been possible without the titanic effort of Arthur Charles Hoffman ’73 MBA ’76.

The Stanford Daily

Dedicated to the understanding, treatment and ultimate cure of substance use disorder by funding cutting-edge research. 


Cure Addiction Now (CAN) is dedicated to the understanding, treatment and ultimate cure of drug addiction. Funding basic research and its clinical translation through a collaborative program is the core focus of the foundation. In addition to creating new therapies to help stop the deadly cycle of addiction, we hope to eliminate the negative stigma of this disease and ultimately find a cure for the brain’s addiction to drugs. 

Background:
Nancy Davis founded CAN in 2018 with her son Jason Davis who tragically passed away in 2020. Jason’s dream was to fund ground-breaking research to find therapies to help stop the vicious cycle of substance use disorder (SUD) and help people not only detox but stay in permanent recovery. CAN also has plans to fund educational campaigns to remove the negative stigma of SUD and change the narrative. Our mission is to cure addiction now. 

At the beginning of Covid 19, one person in the US would die every 11 minutes of an opioid overdose. That number has multiplied dramatically to one person every minute and a half and this does not include other drug overdoses. 70 percent of all deaths are now caused by Fentanyl. Yes, addiction is a real disease and needs to be treated. There is no other disease claiming so many lives. We need to take the stigma of shame away that addicts suffer and treat them with dignity, kindness and compassion the same way we treat everybody else suffering from any disease. We need to raise important funds for our brilliant doctors that represent Mount Sinai, Harvard, UCLA, Scripps, University of Washington and Johns Hopkins and start saving lives. Please Visit our website for more information and a detailed list of our esteemed Scientific Advisory Board and Collaborating Scientists. Below are the currently funded grants from this year. Thank you for your consideration and support!

2021 Grant Awardees: Research Progress Report as of 10/1/2021

Research Project #1: Developing a Strategy to Prevent Relapse to Opioid, Nicotine, 
Alcohol and Cocaine Use with a Single Use Medication
Courtney A. Miller, PhD, Scripps Research

Substance use disorder (SUD) is a chronic, relapsing disorder with a severe lack of treatment options. Associations that have formed during periods of drug use serve as powerful relapse factors by triggering motivation to seek the drug. Recently, we identified the molecular ATPase and driver of synaptic actin polymerization, nonmuscle myosin II (NMII), as a biological target for the selective disruption of these associations. A single treatment with the NMII inhibitor Blebbistatin (Blebb) produces an immediate, seemingly permanent loss of motivation for methamphetamine (METH) and amphetamine (e.g. Adderall) by targeting the associated memories. This occurs without the need for retrieval and without affecting other types of memories, including those associated with other drugs of abuse. In addition to its efficacy in animal relapse models following a single treatment, several properties made Blebb an excellent starting point for medication development. Paramount among these are the molecule’s high brain penetration (thus, lower doses can be used) and rapid clearance from the body and brain (limiting unwanted peripheral and central effects on the body). Unfortunately, Blebb’s activity at cardiac muscle myosin II (CMMII), a protein critical for heart function, was a liability. Through work funded by the NIH, including NIDA, we have developed a preclinical candidate compound, MT-110, that retains Blebb’s high brain penetrance and rapid clearance, but no longer inhibits CMMII. The result is a dramatically improved safety profile and a therapeutic index (ratio of the lowest dose that achieves the desired effect and the highest tolerable dose) of at least 25x. We have filed a non-provisional patent in the US and ten other countries, declared a preclinical candidate, and are now preparing to file an IND with FDA and designing our first in human Phase 1 trial. Recognizing that it would be powerful to utilize the Blebb-based NMII inhibitor to target motivation for other widely used drugs of abuse, particularly opioids, alcohol, nicotine and cocaine, we have begun working on a strategy. Blebb disrupts restabilization of these memories when animals are exposed to reminders associated with the drug of abuse. However, for individuals that use drugs, associations capable of motivating drug seeking can number in the hundreds and even be unconscious motivators. Therefore, it is not feasible for subjects to actively retrieve all “triggers” in a clinical setting for reconsolidation targeting. Interestingly, recent evidence in animal and human studies indicates a similar disruption can be achieved by pairing a reconsolidation disrupting intervention with a small amount of the drug of abuse itself. We now have promising preliminary preclinical data using this strategy that points to the potential for MT-110 in cocaine, nicotine and opioid use disorders. Additional studies to validate and extend these findings are underway. 

Research Project #2: 
Role of chemosensory processing in choroid plexus circuit in drug addiction
Paul J. Kenny, Ph.D. and Stephanie P.B. Caligiuri, M.D., Mount Sinai, New York

Sensitivity to the aversive properties of addictive drugs influences vulnerability to substance use disorders (SUDs). Indeed, aversive reactions to drugs of abuse upon their first usage decreases the likelihood that subsequent use will transition from occasional to habitual. Little is known about the mechanisms of drug aversion. Taste systems guide ingestive behaviors to ensure survival by detecting sweet, salty, & umami flavors, which represent carbohydrates, electrolytes, and protein respectively. Taste systems also detect sour and bitter tastes, which often reflects spoiled or poisonous substances. Intriguingly, most addictive drugs are bitter-tasting plant-derived alkaloids, a class of compounds known to activate taste-2 receptors (T2Rs). In addition to their abundant expression in the oral cavity, accumulating evidence suggest that T2Rs are also expressed outside the oral cavity. Individuals carrying genetic variation in genes that encode components of the T2Rs and related signaling machineries are at increased risk of developing SUDs. With the support of Cure Addiction Now (CAN), we are testing the hypothesis that oral and/or extra-oral T2Rs are activated by opioids and other classes of addictive drugs, and that this action contributes to their aversive properties that protect against SUDs. Using genome editing technologies and cellular assays of T2R function, we have collected compelling data suggesting that drugs of abuse stimulate T2R signaling. We have also shown that the same neurons in brain aversion centers that are activated by consumption of noxious bitter compounds such as quinine are also recruited by drugs of abuse. Moreover, we have shown that genetic manipulations that selectively perturb T2R signaling attenuated aversive responses to drugs of abuse and increases their consumption. Perhaps most surprisingly, we found that T2R-mediated aversive sensory information related to drugs of abuse is routed to the choroid plexus in the fourth ventricle, a secretory organ in the brain, and that manipulating genes in the choroid plexus regulates aversive behavioral responses to addictive drugs. These data reveal a novel chemosensory mechanism that regulates addiction-relevant behavioral responses to drugs of abuse that may serve as a substrate for the development of target therapeutics for SUDs. 

Research Project #3
The Kappa Opioid Receptor: A Therapeutic Target for Negative Affect in Pain and Addiction
Catherine Cahill, Ph.D. and Edythe London, Ph.D., UCLA

Anhedonia is the impaired capacity to experience pleasure from naturally rewarding objects and events.  It is defined as a state of ‘markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day’.  While it is relatively undertreated, it occurs in many neuropsychiatric disorders including substance use disorders and chronic pain. Considering the high comorbidity between negative affective states, such as depression and chronic pain, it is not surprising that anhedonia may be a driver of opioid addiction, where opioid misuse is a predictor of anhedonia. 

Kappa opioid receptor agonists produce dysphoria, depressive-like symptoms and psychotomimetic effects in humans, and they elicit aversion and depressive-like behaviors in preclinical models. A novel kappa receptor antagonist JNJ-67953964 produced anti-anhedonic effects in a recent, multicenter, double-blind, placebo-controlled, randomized clinical trial.  Given the involvement of this receptor in negative affective states and the positive preliminary clinical study in alleviating anhedonia, our studies focus on kappa receptors with the goal of facilitating the development of medications for Opioid Use Disorder.

Our first aim was to determine the association of kappa binding in limbic regions of brain with measures of negative affect in a model of chronic pain. To date, we have demonstrated kappa receptor binding in the striatum using microPET and 18F]LY2459989, a novel kappa radiotracer. Binding of this tracer was blocked by both a kappa-receptor selective antagonist the nonselective opioid antagonist naloxone.  We have also conducted longitudinal studies were animals were imaged over time to correlate changes in receptor binding with the development of negative affective states.  Analysis of these data are ongoing.

Studies in people who misuse heroin show that acute opioid withdrawal increases opioid craving and seeking behavior, and that the severity of withdrawal predicts the response to treatment.  We therefore have conducted microPET imaging in opioid-dependent rats during the acute phase of opioid withdrawal. Analysis of these studies are ongoing.



Cure Addiction Now

Techqueria is a 501(c)(3) nonprofit that serves the largest global community of Latinx professionals in the tech industry 🌮

Our mission is to provide Latinx professionals with the resources and support that they need to drive their careers, enable them to thrive, and become leaders in the tech industry.

Techqueria

Further Health helps you advance amazing biomedical research that are reshaping how people live healthier for longer.

Further Health focuses on advancing the most incredible biomedical research efforts that make it possible for people to enjoy healthier lives for longer.

Your donations help our team expand public awareness and advance scientific understanding on how to prevent and reverse diseases, injuries, and disorders using next-generation treatments.

Further Health, Inc.

Zig is a general-purpose programming language and toolchain for maintaining robust, optimal, and reusable software.

The Zig Software Foundation is a non-profit corporation founded in 2020 by Andrew Kelley, the creator of Zig, with the goal of supporting the development of the language. Currently, the ZSF is able to offer paid work at competitive rates to a small number of core contributors. We hope to be able to extend this offer to more core contributors in the future.

Zig Software Foundation Inc

Organization, founded in 2005 that promotes student achievement and career exploration in math and science for K-12 students by connecting them with individuals with STEM Backgrounds

SEM Link’s mission is to strengthen the self-efficacy of K-12 students to pursue STEM careers by exposing them to positive adult role models from the Science, Technology, Engineering and Mathematics (STEM) community that increase students' awareness of STEM careers and encourage their participation in STEM Research through digital learning and hands-on activities.

Science, Engineering and Mathematics Link Inc

Developing open source privacy technology that protects free expression.

Long before we knew that it would be called Signal, we knew what we wanted it to be. Instead of teaching the rest of the world cryptography, we wanted to see if we could develop cryptography that worked for the rest of the world. At the time, the industry consensus was largely that encryption and cryptography would remain unusable, but we started Signal with the idea that private communication could be simple.

Since then, we’ve made some progress. We’ve built a service used by millions, and software used by billions. The stories that make it back to us and keep us going are the stories of people discovering each other in moments where they found they could speak freely over Signal, of people falling in love over Signal, of people organizing ambitious plans over Signal. When we ask friends who at their workplace is on Signal and they respond “every C-level executive, and the kitchen staff.” When we receive a subpoena for user data and have nothing to send back but a blank sheet of paper. When we catch that glimpse of “Signal blue” on a metro commuter’s phone and smile.

However, we’ve always wanted to do much more, and our limitations have often been challenging. Over the lifetime of the project, there have only been an average of 2.3 full-time software developers, and the entire Signal team has never been more than 7 people. With three client platforms to develop, a service to build and run, a growing list of integrations to assist with, and millions of users to support, that has often left us wanting.

Even so, Signal has never taken VC funding or sought investment, because we felt that putting profit first would be incompatible with building a sustainable project that put users first. As a consequence, Signal has sometimes suffered from our lack of resources or capacity in the short term, but we’ve always felt those values would lead to the best possible experience in the long term. The Signal Foundation completes our vision of Signal operating as part of a full 501(c)(3).

Signal Technology Foundation

SJPLF provides advocacy, financial support, and leadership to our public libraries and educational programs throughout San Jose.

At the heart of our community, libraries provide a place where everyone can learn, create, study and explore. Mrs. Ruth Kampa – a former librarian and President of the Library Commission — embraced this with her strong passion for the Library. In 1987, Ruth had the foresight to setup the San José Public Library Foundation (SJPLF) so that the Library could receive more than just public funding. In 1992, Ruth passed away and because of her bequest the Foundation was able to hire its first paid staff member. According to the original board members, “that was the tipping point that really put the Foundation in business.” The Foundation has changed and grown over the years but Ruth’s legacy to raise funds for our San José libraries still continues today.



San Jose Public Library Foundation

An organization focused on education. It received its nonprofit status in 2021.

10 Academy Corp

CLEAR Global is a nonprofit helping people get vital information and be heard, whatever language they speak.

CLEAR Global is a US-based nonprofit comprising Translators without Borders, CLEAR Tech, and CLEAR Insights. We're helping people get vital information and be heard, whatever language they speak. With our innovative language technology solutions, research, and community of over 80,000 linguists, we support partner organizations working in various contexts around the world. We have local teams in Nigeria and Bangladesh, and are actively helping people affected by natural or man-caused crises get the information they need and understand.

As we envision a more linguistically just and diverse world, we started a movement. Our Four Billion Conversations movement is about helping bridge the digital language divide, and improving global information and communication access to include people who speak marginalized languages into matters that concern them as well. Part of this initiative is our language technology, including multilingual conversational chatbots and voice-enabled interactive information kiosks, thanks to which people can get answers to their questions instantly and securely.

We released a plethora of language data resources, such as the Global Language Data Review, a useful resource for planners to make their programs and services more inclusive, and language maps and glossaries that help humanitarians and other responders better communicate with local communities living through crises.

CLEAR Global

We are New Harvest, the cellular agriculture nonprofit. We’re growing meat, milk & eggs from cells instead of animals.

New Harvest was founded in 2004 to support the development of cultured meat (AKA “lab-grown meat”) and other cell culture-based foods. 

Our mission is to ensure cellular agriculture delivers on its promises to create a more equitable & sustainable food system by ending our dependence on animal agriculture. 

We fund public research and industry-wide initiatives to accelerate scientific breakthroughs and steward this tech toward making the world a better place. 

New Harvest

A prep program connecting young men of color to the tech industry.

All Star Code creates economic opportunity by developing a new generation of boys and young men of color with an entrepreneurial mindset who have the tools they need to succeed in a technological world. All Star Code envisions a country where all young men of color have access to the tools of success, where the ability to thrive is available to all who are willing to dare greatly.

All Star Code

We do foundational mathematical research to ensure smarter-than-human artificial intelligence has a positive impact.

The Machine Intelligence Research Institute is a research nonprofit studying the mathematical underpinnings of intelligent behavior. Our mission is to develop formal tools for the clean design and analysis of general-purpose AI systems, with the intent of making such systems safer and more reliable when they are developed.

The field of AI has a reputation for overselling its progress. In the “AI winters” of the late 1970s and 1980s, researchers’ failures to make good on ambitious promises led to a collapse of funding and interest in AI. Although the field is now undergoing a renaissance, overconfidence is still a major fear; discussion of the possibility of human-equivalent general intelligence is still largely relegated to the science fiction shelf.

At the same time, researchers largely agree that AI is likely to begin outperforming humans on most cognitive tasks in this century. Given how disruptive domain-general AI could be, we think it is prudent to begin a conversation about this now, and to investigate whether there are limited areas in which we can predict and shape this technology’s societal impact.

Researchers at MIRI tend to be relatively agnostic about how the state of the art in AI will change over the coming decades, and how many years off smarter-than human AI systems are. 

Machine Intelligence Research Institute

Koko is a tech-based nonprofit that brings mental health and well-being to millions of people.

Koko is a tech-based nonprofit created by a team out of Airbnb and MIT. Our mission is to bring mental health and well-being to as many people as possible. We believe the best way to do this, the best way to help millions of people, is to reach people where they are — online. 

We work with social networks and large online communities, arming them with the tools to make a measurable impact on the health and well-being of millions of people, especially young adults. Our services have reached 2 million people so far, mostly adolescents.




Koko

Dedicated to inspiring and preparing youth for successful, thoughtful, and ethical engagement in STEM and related professions.

The mission of the National Youth Science Foundation is to inspire lifelong engagement and ethical leadership in science, technology, engineering, mathematics, and related professions through its proven educational model for mentoring, challenging, and motivating students. By building communities among students, teachers, and professionals, NYSF programs complement, broaden, and enhance the traditional school curriculum leading to careers in science, technology, engineering, mathematics, and related professions.

National Youth Science Foundation

Dedicated to preserving biodiversity through grass-roots conservation programs.

The Rare Species Conservatory Foundation is dedicated to preserving biodiversity through grass-roots conservation programs rooted in sound science.  RSCF employs the "Flagship Species" concept to identify and conserve high-profile, priority species in order to leverage protection for the ecosystems they represent.

RSCF's South Florida facility houses critically endangered species. We specialize in creating breeding and recovery strategies for some of the world's most vulnerable species and ecosystems. From captive breeding and reintroduction to land management and environmental policy, RSCF's teams of biologists, students and animal care specialists create targeted strategies and solutions to protect and preserve wildlife and wild places. Extinction is not an option.

Rare Species Conservatory Foundation

Strengthening democracy for all voters by promoting the responsible use of technology in elections.

Verified Voting’s mission is to strengthen democracy for all voters by promoting the responsible use of technology in elections. We are a non-partisan organization focused exclusively on the critical role technology plays in election administration. Our staff, Board, and Board of Advisors consist of nationally-recognized subject matter experts on the issue of election integrity and the responsible use of technology. Since our founding in 2004 by computer scientists, we have acted on the belief that the integrity and strength of our democracy rely on citizens’ trust that each vote is counted as cast. In the ever-shifting world of election security, where new threats or challenges can emerge at any time, we are working to guide elections toward greater accuracy, security, and verifiability.

Verified Voting

VillageReach transforms health care delivery to reach everyone. 

VillageReach transforms health care delivery to reach everyone, so each person has the health care they need to thrive. 

Last year, we increases the availability of quality health care for more than 58 million people across sub-Saharan Africa by increasing access to medicines and vaccines, improving the capacity of the health workforce and enabling better decision-making for patients, health workers and policy-makers.

VillageReach

Pelican Harbor Seabird Station is dedicated to the rescue, rehabilitation & release of sick, injured or orphaned native wildlife.

Mission: Pelican Harbor Seabird Station is dedicated to the rescue, rehabilitation and release of sick, injured or orphaned brown pelicans, seabirds and other native wildlife; and the preservation and protection of these species through educational and scientific means.

Vision: As a trusted wildlife rehab center, Pelican Harbor Seabird Station embodies professionalism, compassion, and integrity. Through innovation, education, and outreach, we provide the highest quality of patient care while promoting the importance of conservation in the community.

Pelican Harbor Seabird Station

Hope Neighborhood Learning Center is a 501c3 focused on literacy intervention and STEAM education.

Hope Technologies Sacrament Inc, doing business as, Hope Neighborhood Learning Center is a community development based non-profit 501(c)(3) organization focused on serving youth through mentoring, discovery and encouragement.

Our Programs: Hope Literacy and Hope Tech.

The Hope Literacy program is a place for children to overcome academic challenges and be inspired in lifelong learning.

The Hope Tech program is designed around S.T.E.A.M. (Science, Technology, Engineering, Arts and Math) where students learn 21st century skills to create their own platformer games.

Our Culture: Be Bold, Encourage and Explore

Boldly try new things. You may not know how to do something, but that shouldn’t stop someone from trying or asking others about how to do something. New things come to be because someone was able to realize something that had never been done before.

As we boldly try new things we often become discouraged because of the challenges we face. We are a community that provides encouragement to try again and take another step. We celebrate moments of success and come alongside during difficult hurdles.

In order to learn, we believe that students must explore and be incessantly curious about the world around them.

Hope Neighborhood Learning Center

We build computer labs in rural schools. We want to disrupt poverty by empowering African youth to join the digital economy.

TechLit Africa

Ozark Natural Science Center’s mission is to enhance understanding, appreciation and stewardship of the Ozark natural environment.

Our History...
 
Beginning in 1989, a small group of individuals guided by Ken and RuAnn Ewing of Rogers started meeting with the single purpose of developing a concept plan for a residential field science center in the Arkansas Ozarks. Those early planning sessions resulted in The Ozark Natural Science Center incorporation in 1990 and subsequent non-profit, 501 (c)(3) status in 1993.
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In 1992, the Center hosted its first residential program: a two-week Wet’n Wild camp, part of the Arkansas Enrichment for the Gifted in Summer (AEGIS) program of the Arkansas Department of Education. Since the science center was under construction, campers stayed in platform tents and dined in a partially completed dining room. By 1994, the Ewing Centre was complete and housed administrative offices and the kitchen and dining hall. That same year, ONSC began offering residential school-based programming for 700 Rogers and Bentonville fifth grade students.
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Today...
 
Currently, the central campus includes three lodges, an education building, guest housing, faculty housing, the Stewart Springfield Memorial Outdoor Classroom, an observation deck, and almost eight miles of maintained hiking trails. ONSC’s school-based programming now offers hands-on, experiential field science opportunities to more than 3,000 students from northwest and central Arkansas and northeast Oklahoma..
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Ozark Natural Science Center

From microbes to alien intelligence, the SETI Institute is the only organization dedicated to the search for life beyond Earth.

Have you ever looked at the stars and wondered if humans are alone in the universe?

The SETI Institute is a non-profit dedicated to the exploration and understanding of life on Earth and beyond. Our researchers are working to understand humanity's beginnings and our place among the stars. 

The SETI Institute runs the Allen Telescope Array, the first observatory built from the ground up to search for signals from technologically advanced societies in nearby star systems. Since federal funding for SETI research like this is limited, our donors have carried the torch for humanity in searcing the universe for other intelligent species. 

But life comes in all sizes, and just because there aren't other intelligent species in our solar system, doesn't mean there isn't microbial life on Mars or under the ice of Europa. Our scientists study extreme environments and the microbes that inhabit them so we are better prepared to search for life on planetary bodies throughout the galaxy. For example, the SETI Institute has a long history of supporting Mars exploration, including the search for biosignatures and the understanding of the planet's past climate. 

And research is only a part of what we do. We are also committed to educating the next generation of SETI scientists and public programming on science topics critical to all of humanity.

Where will you be when we find life beyond Earth? Join the search today.


SETI Institute

We sustainably reuse technology, enable digital access and provide education to create a community that empowers people to realize their potential.

Drop off your tax-deductible donations of used electronics and we'll train volunteers to refurbish them for grants to other nonprofits and schools. Come check out The Free Geek Store for affordable used electronics.

FREE GEEK

A new initiative to advance forecasting and epistemics for the aim of improving the long term future of humanity.

We research systematic practices to specify and estimate the most important parameters for the most important or scalable decisions. Research areas include forecasting, epistemics, evaluations, ontology, and estimation. We emphasize technological solutions that can heavily scale in the next 5 to 30 years.

We believe that humanity’s success in the next few hundred years will lie intensely on its ability to coordinate and make good decisions. If important governmental and philanthropic bodies become significantly more effective, this will make society far more resilient to many kinds of challenges ahead.

Quantified Uncertainty Research Institute

Podsie is an edtech nonprofit dedicated to empowering teachers and improving student learning outcomes.

Podsie is an edtech nonprofit dedicated to empowering teachers and improving student learning outcomes. We've built a a free learning tool for teachers that helps their students remember what they've learned. We make it easy for teachers and students to review in a personalized and efficient way that's backed by learning science principles.

Podsie

We are a biomedical research institute working toward a fundamental understanding of biology to drive advances in human health.

Our mission is to improve human health through innovative, interdisciplinary biomedical discoveries, spark scientific curiosity and serve society through translational outcomes, in partnership with the University of Wisconsin-Madison.

Our Core Values
1. Curiosity: We embrace and encourage bold questions. We conduct fearless science and follow the results where they take us.
2. Collaboration: We can’t do this alone. We partner with the University of Wisconsin-Madison to achieve the greatest outcomes.
3. Integrity: We pursue our mission with rigor, discipline and honesty. We treat everyone with dignity and respect and are committed to equality.
4. Inspiration: We believe society is strengthened by science. We connect with communities to spark imagination.

Morgridge Institute Foundation Inc

Conservation from Ridge to Reef  --- Conservación de los Altos hasta los Arrecifes

We aim to restore and protect the endangered dry tropical forest and coastal ecosystems of Mesoamerica's Pacific Slope.

Our innovative approach protects biodiversity where people already live. By working with local communities, landowners, and partner organizations, we restore and protect the habitats that form building blocks for wildlife corridors.

We began developing our first corridor in 2005 in Nicaragua’s Paso del Istmo Biological Corridor. In 2018, we began working in El Salvador as well. By strengthening the Paso del Istmo and other corridors across a region-wide network, we will reconnect people and wildlife across western Mesoamerica — with your support.

Paso Pacifico

We create medical technology for everyone, and believe in a world where we all have access to world-class medical treatment.

We are a global team of designers, engineers, medical professionals, and business minds, working out of India, Kenya, and USA. We are united by our belief that no matter where you live, you should have access to world-class medical treatment.

Our medical products help increase maternal and newborn survival rates, improve mobility, and scale world-class, affordable solutions across more than 70 countries.

Equalize Health was founded in the late 2000s under the name D-Rev. The world had just woken up to the potential of design to address the world’s greatest inequalities.

In our early days, we sought to develop solutions for areas as diverse as economic empowerment, agriculture, and education. Our Brilliance phototherapy device became a benchmark in the design for impact space.

Today, we are focused entirely on health, where we believe the greatest inequity exists. Without health, it is difficult to go to school, to work, or function in society. For people to thrive, they must be healthy. We are proud to have made a significant impact in this area, having treated over one million patients worldwide.

Equalize Health

To empower and mentor those most underrepresented in tech, to be tech innovators through hands-on computer science training.

CodeCrew directly addresses the diversity and access gap in tech. We offer educational opportunities that 1) teach children and adults to code while mentoring them toward careers in tech fields, and 2) provide educators the tools to increase computer science knowledge for all students, we are introducing an entire generation to the 21st century skills foundational to individual success.  

CodeCrew is directly addressing that access gap in Memphis. By offering educational opportunities that 1) teach children and adults to code while mentoring them toward careers in tech fields, and 2) provide educators the tools to increase computer science knowledge for all students, we are introducing an entire generation to the 21st century skills foundational to individual success.  

Our tech education programs do not just teach students how to write code or produce software applications. Our programs enable creative, analytical thinking, encourages students to be focused both on big picture outcomes and detail-level execution, and allows them to develop their leadership skills and to take ownership of their decisions. Computer science training teaches students to take pride in what they do, to accept feedback and peer criticism, and be excited about sharing their work with the world.  High levels of computer science education transform students into highly paid employees and entrepreneurs, as well as highly effective citizens.  Memphis is finally positioned to become a significant pipeline of African American and Latino tech talent for the future.  But we must continue our efforts.

Our K-12 Programs
In-school electives
Grizzlies After-school Program
Grizzlies Summer Code Camp
Exposure Events: Hackathon & Hour of Code
Teacher Professional Development
Policy and Advocacy

Adults
Code School: https://www.code-crew.org/codeschool
Code 101; Code 102, Code 201, Code 301, Code 401


CodeCrew

What's your passion? Bellingham Makerspace is your one-stop resource for creative tools and learning. Support our community today!

Bellingham Makerspace

Triple F Empowerment Inc, the Harlem non-profit that operates Ms. Steph's Science Club. We provide fun science classes for youth. 

Looking ahead into 2022, we, as an organization, are resetting our hypothesis (like the science buffs we are) to test the theme for 2022 of Why STEAM? This is to answer for our community why Science, Technology, Engineering, Arts, and Math (STEAM) are integral subjects in the daily lives of our students. 

This answer comes in the myriad of instances where our students, having learned and reinforced a new concept at Science Club, are then able to retain and apply said concepts in other settings. Dejah, for instance, recently tested in school on a concept in her middle school science class. She was able to excel on the exam due to her having learned these very concepts 18 months prior in Science Club! Through Ms. Steph’s Science Club, students are exposed to fundamental lessons that prime them as subject matter experts starting as early as pre-school. 

 The community of students we serve, from pre-school through high school and alumni (college and beyond) managed through Summer Science Club and our in-school programming with a renewed excitement, even though the prolonged pandemic, and new in-school/in-person safety protocols. We were able to use our circumstances to our benefit to teach our curriculum in multiple ways through in-person as well as virtual programming. 

We know Ms. Steph’s Science Club makes a difference in the lives of hundreds of students, their families, and the communities within which they reside. You can help us grow our programming and the reach of our STEAM curriculum, with your one-time gift or monthly contributions. Your impact covers the following: 

- Operating budget to fund staffing and program operations 
- Traveling Science Teacher staffing and partnerships 
- Saturday Science club staffing and science kits 
- Summer Science Club preparation and science kits 
- Virtual learning equipment

Won't you help us empower the next generation of STEAM professionals by pledging your monthly contribution today?

Triple F Empowerment Inc

The Equal Vote Coalition is the driving force behind STAR Voting and a leading proponent of better voting methods in general.

The Equal Vote Coalition's mission is to promote true equality in the vote. The Equal Vote Coalition mandate is top-notch research, community education, and coalition building.

Our five core criteria for electoral reform are: Equality, Honesty, Accuracy, Expressiveness, and Simplicity. These criteria form the basis by which we evaluate and advance proposals for better voting.

Equal Vote Coalition

Washington’s National Park Fund is the official philanthropic partner to Mount Rainier, North Cascades, and Olympic National Parks

We raise private support to preserve and protect Washington’s cherished national parks: Mount Rainier, North Cascades, and Olympic. With your help, we fund youth and family experiences, scientific research, and projects that will keep our parks strong and vital now and forever, for everyone.

Here's how it works: Each year, the three park superintendents and their staff identify critical projects in need of support. With our community, WNPF raises the funds to make these projects a reality. Together, we sustain between 30 and 40 projects and programs each year that would otherwise go unfunded.

But we can't do it without your help.

Washington's National Park Fund

Accelerates the development of sustainable animal-free materials for the fashion, automotive, and home goods industries.


From your car seat to the clothes on your back, the materials we interact with every day have a profound impact on the environment. Animal-based materials are linked to climate change, chemical waste, and resource depletion, and many current animal-product replacements are made from petroleum and don’t meet consumers’ needs. Consumers and companies alike are searching for sustainable solutions that are functional, fashionable, and cost-effective, but today’s options are few and far between.
The Material Innovation Initiative accelerates the development of sustainable materials for the fashion, automotive, and home goods industries, with a focus on replacing animal-based materials.

Material Innovation Initiative

We train young people to solve the world's biggest problems using tech. Our goal is to help billions by unlocking human potential.

Are you interested in shaping the future of education? According to the World Economic Forum (WEF), education systems have grown increasingly disconnected from the realities and needs of global economies… With your help, we can change that. 

Unlike traditional education, The Knowledge Society (TKS) doesn’t care about conventional metrics like grades or extracurriculars. We care about curiosity, ambition and the desire to make a big impact in the world. We then equip these young change-makers with the knowledge, skills, and an environment of encouragement to solve some of the most important problems of our times, transforming these ordinary teens into “tech superheroes”. TKS has been recognized by WEF as a School of the Future. 

How do we do it? Students from across North America participate in a 10-month accelerator program with weekly sessions on emerging technologies in areas like artificial and nanotechnology that are changing the world. They participate in real-world challenges that companies are currently facing with a community of like minded peers. They earn access to top-tier mentors and unique opportunities like conferences, speaking engagements and internships. They develop foundational mindsets like gratitude and first principles thinking which will help them make a significant impact on the world. This is a program unlike any other. 

The result? TKS students have gone on to work at leading startups and tech companies, earn research positions in cutting-edge research labs and even land VC funding to bring their projects to life. Our students are using emerging technologies to tackle the biggest problems in the world you care about: health, climate change, data security, and social inequality. 

Your donation will keep TKS accessible to all students, regardless of their family’s financial means. Many of the most impactful transformations and top-performing students are from low-income families. Every $5000 invested in TKS provides access for one student to participate in this life-changing program. We invite you to help us build the next generations of world-changers.

The Knowledge Society

The Dauphin Island Sea Lab Foundation assists in developing resources that ensure the long-term growth of the DISL. 

Dauphin Island Sea Lab Foundation Mission 
The Dauphin Island Sea Lab Foundation supports the Dauphin Island Sea Lab in its mission, “to provide wise stewardship of the marine environment through education and research”. 
 The foundation provides funds to sustain the activities of the DI Sea Lab and promotes 
 awareness of the DI Sea Lab and environmental issues. 
 The Foundation is also building an endowment for the Dauphin Island Sea Lab.

The Dauphin Island Sea Lab Overview

The Dauphin Island Sea Lab (DISL) is the state of Alabama’s marine research and education center. DISL was founded in 1971 by the Alabama Legislature, to maximize the state's marine sciences capabilities and minimize program duplication at Alabama colleges and universities.  Four historically black colleges and universities, both public and private, are among the twenty-two Alabama colleges and universities served by DISL. DISL was recently named the Restore Act-funded Alabama Center for Excellence by the Alabama Gulf Coast Recovery Council.

The DISL University Programs include both graduate and undergraduate courses taught throughout the academic year. This provides about two dozen courses and 1,700 credit hours for upwards of 200 students from the member institutions. DISL does not grant degrees, however, more than 250 graduate degrees have been awarded to DISL based students over the past 25 years.
The DISL Discovery Hall Programs offers a K-12 program that serves students from the entire state of Alabama. It engages classroom teachers and students in the study of marine science throughout the year resulting in more than 55,000 contact hours with over 17,000 students. Opportunities include internships, field trips, service learning, mentoring programs, camps, professional workshops, and more. The traveling BayMobile takes marine science to children in under-served schools reaching over 8000 students.
Public education is offered on campus through the public aquarium, recently named the official Aquarium of Alabama. The Alabama Aquarium focuses on the Mobile watershed, Mobile Bay, and the Gulf of Mexico introducing visitors to marine habitat and marine life through live exhibits and hands-on experiences.

The Role of the Dauphin Island Sea Lab Foundation
The Dauphin Island Sea Lab Foundation was established in 2002 to assist in developing new resources that ensure the long-term growth of the DISL. The founding trustees recognized that the availability of the State to aid the Lab in achieving its full potential is limited, and the Sea Lab must continue its role as a national leader in research, science education, and coastal policy development.



Dauphin Island Sea Lab Foundation

Pioneers research, outreach & cooperative efforts with other organizations worldwide

Our mission is to support the health and well-being of people affected by autism through innovative, impactful research and education.
Causes of ASD remain unclear but recent scientific advances challenge the traditional view of autism as an untreatable disease—as one that is “genetically hard-wired.” These developments support the position that Autism Research Institute (ARI) has always maintained: Autism Is Treatable. Established in 1967 by psychologist and renowned father of modern autism research Dr. Bernard Rimland, ARI continues to pioneer in research, outreach, and cooperative efforts with other organizations worldwide. ARI advocates for the rights of people with ASD, and operates without funding from special-interest groups.

Autism Research Institute

YTB Queenhythe Community Center - Power-Internet-Digital Inclusion - and youth who are change makers in their community. 

Hello, YTB Queenhythe Community Center is a place, finally, for youth in St. Ann's Parish, Jamaica, to have a place to go to for support, activity, and technology inclusion.  And a place to gather for Youth TimeBanking - a place to for youth to build their team, make connections, and be the change in their community.  Youth power make our community stronger!

YTB Queenhythe

We're finding solutions to the world’s most pressing problems through evidence-led and thoughtful approaches to impact.

Founders Pledge is a community of over 1,700 tech entrepreneurs finding and funding solutions to the world’s most pressing problems. Through cutting-edge research, world-class advice, and end-to-end giving infrastructure, we empower members to maximise their philanthropic impact by pledging a meaningful portion of their proceeds to charitable causes. Since 2015, our members have pledged over $7 billion and donated more than $700 million globally. As a non-profit, we are grateful to be community-supported. Together, we are committed to doing immense good.