اللهم صلّ و سلم و بارك على محمد و آل محمد

Zig is a very sharp tool, that is exactly what I need.

ConnectMyVariants work in the community saves lives! 

High quality medical services for marginalized groups in Cairo and the region.

Mersal Foundation for Charity and Development is a non-profit organization that serves in the health field and works on providing all types of healthcare with high quality to whoever is in need.

**Vision**
To be the number one medical organization in Egypt and the Arab region and proactive in ensuring the right in healthcare for the marginalized groups and those who are in need the most.

**Message**
Working on analyzing and filling the gaps of the healthcare system to provide high quality medical services on the basis of equality and dignity through enabling a charitable healthcare system for whoever cannot afford it, as well as contributing to the development of the health sector.

**Objectives**  

- Providing medical services to whoever deserves them regardless the cost or for how long they will be needed.
- Spreading medical awareness in all the places it serves in.
- Achieving sustainability in funding its activities Core Values.
- Privacy: Mersal ensures the patient's eligibility to receive its services without hurting their dignity or exposing them to any kind of embarrassment.
- Healthcare With No Discrimination: Mersal is an open arm to all patients with no discrimination whatsover; whatever religion, nationality, color, or language, all patients in need are welcomed to receive the organization services.
- High Quality: Mersal provides all types of medical services in the highest possible quality through its network of specialized medical personnel.
- Credibility and Transparency: Mersal announces the size and sources of its fund as well as its administrative and medical expenditures, The foundation financial reports and annual budgets are available through several outlets through which any person can explore how resources are managed. Mersal believes in the importance of being specialized in specific fields and its early choice was the healthcare services.

In the past six years, the organization registered over 25,000 patients from 27 provinces.  Mersal has been seeking to enable access to its services all over the country. And the dream of helping those who are in need whoever they are and whatever the cost and time is still alive, Mersal has worked over the past six years on getting close to its patients throughout their treatment journey.

Mersal Foundation for Charity and Development 

Zig is a general-purpose programming language and toolchain for maintaining robust, optimal, and reusable software.

The Zig Software Foundation is a non-profit corporation founded in 2020 by Andrew Kelley, the creator of Zig, with the goal of supporting the development of the language. Currently, the ZSF is able to offer paid work at competitive rates to a small number of core contributors. We hope to be able to extend this offer to more core contributors in the future.

Zig Software Foundation Inc

ConnectMyVariant's mission is to end hereditary disease by bringing families together.

ConnectMyVariant is an educational health-focused 501(c)3 nonprofit organization that supports individuals and families with hereditary disease in their early detection and prevention efforts. We provide unique value by leveraging our evidenced-based family connection protocols to help people identify other at-risk relatives and help those relatives access genetic testing so that they can get optimal medical care. ConnectMyVariant brings people with the same genetic risk together through our variant database and community engagement events to share experiences and find common ancestors. ConnectMyVariant also works to increase awareness of the benefits of family outreach among physicians, others who provide prevention care, and the broader genealogy community.
 
Our key activities are:

- Working with patients to implement personalized family outreach plans
- Interactive educational workshops about sharing information on inherited disease risk
- Variant specific family reunions to share stories and plan outreach to cousins
- Genealogy assistance to help connect individuals in variant groups
- Individual equity and inclusion grants for family and community outreach

Need and Impact:
When hereditary disease risk is known, family outreach has been proven to be the most effective and cost-effective intervention for early detection and prevention. This family outreach, also known as cascade testing, is recommended by multiple guidelines. Despite overwhelming evidence, family outreach assistance is not reimbursed by insurance or integrated into healthcare. Many people suffer and die from hereditary disease that could have been prevented or caught early.
 
We have shown that our strategies to encourage family outreach can act as a communication multiplier. Our pilot research at the University of Washington showed that this approach enhanced patient experience, was considered ethical, and was appreciated by newly identified relatives. Our approach is low-cost and is 25 to 50 times more effective than awareness and education interventions that target the general population.

Equity and Inclusion:
ConnectMyVariant is committed to being a leader for equity, diversity, and inclusion in hereditary disease prevention. ConnectMyVariant’s goal is to spread awareness among all individuals and families about inherited disease risk. All project staff, participants, and partners in ConnectMyVariant have an equal voice in developing innovative ways to improve hereditary disease outreach and prevention for all people. By fostering a diverse and inclusive community, we can provide knowledge and opportunities that have been historically inaccessible to millions of people.

ConnectMyVariant

We match donations to any charity you choose while introducing you to super-effective charities. Learn more: GivingMultiplier.org

[**Giving Multiplier**](https://givingmultiplier.org) is a research project created at Harvard University that adds matching funds to any charity of your choice while introducing donors to highly effective charities recommended by experts.

*Resources:*

- [Make a donation that gets matched](https://givingmultiplier.org)
- [Become a matching funder](http://givingmultiplier.org/matching) (Donations made on this page will also go toward our matching system.)
- [Sign up to our newsletter](http://eepurl.com/i0GHhc)
- [Learn about our philosophy](https://givingmultiplier.org/philosophy)

Questions? Email us: **info@givingmultiplier.org**

Giving Multiplier

Eliminating obstacles on the path to the comprehensive medical control of aging and age-related disease.

Longevity Escape Velocity (LEV) Foundation exists to conduct and inspire research to proactively identify and address the most challenging obstacles on the path to the widespread availability of comprehensively effective treatments to prevent and reverse human age-related disease.

Longevity Escape Velocity Foundation

We aim to mitigate catastrophic risks from transformative AI, which we believe could be developed in the next few decades.



The AI Risk Mitigation Fund (ARM Fund) is a non-profit fund making grants in technical research, policy, and training programs for new researchers to reduce catastrophic risks from advanced AI.

We are focussed on the following three areas.

Technical AI alignment research
Technical research can uncover dangerous capabilities before it’s too late, or enable designing future AI systems with enhanced interpretability, steerability, and possibility for human oversight.

Policy
Policy work aims to ensure that government regulation and corporate standards appropriately guard against catastrophic risks.

Training for new researchers
Investment has poured into AI capability development, yet strikingly few researchers are working on key problems in AI safety, particularly outside major industry labs. Grants in this area aim to bring new talent into the AI safety field.

Our mission is to mitigate catastrophic risks from transformative AI, which we believe could be developed in the next few decades.

Our team and history
Our team works hard to ensure you make the most effective donations possible. We have substantial experience managing large donations securely, professionally, and flexibly. We've collectively overseen tens of millions of dollars worth of donations to nonprofits based on careful analysis of their impactfulness and ability to use new funding.

What you can expect if you donate
When we receive a donation designated for the ARM Fund, we grant 100% of the value of the donation (minus any fees charged by payment processors) to organizations and individuals recommended by our team of expert grantmakers.

The ARM Fund does not take any fees from donations before the distribution (we fundraise separately for our overhead costs, which include wages for our grantmakers).

The ARM Fund will likely have a partially overlapping group of applicants as the Long-Term Future Fund. So while 100% of your donations will go directly to AI safety projects under the ARM Fund, your donations will likely have an indirect effect in freeing up some of LTFF’s other resources to be spent on other existential security interventions, including both in AI safety and in other LTFF focus areas like biosecurity.

Donors will have the option to join our quarterly mailing list tracking updates in AI safety, listing our grants, and more.

100% of your donation is tax-deductible to the extent allowed by US law. Your donation is made to Every.org, a tax-exempt US 501(c)(3) charity that grants unrestricted funds to Effective Ventures Foundation USA, Inc. on your behalf. As a legal matter, Every.org must provide any donations to Effective Ventures Foundation USA, Inc. on an unrestricted basis, regardless of any designations or restrictions made by you.

AI Risk Mitigation Fund

Innovate Animal Ag facilitates the development and adoption of new technologies that improve animal health and welfare


Innovate Animal Ag is a 501(c)3 nonprofit think tank that promotes technology as a practical way to solve the biggest challenges in farmed animal welfare. We conduct and publish research on cutting edge technologies in animal agriculture that improve farmed animal welfare and also offer concrete benefits to farmers. We then facilitate the adoption of these technologies through directly working with agricultural producers that are interested in better meeting the demands of the modern consumer.

Technology is powerful because it eliminates tradeoffs - it can allow us to continually improve the lives that animals live on farm, while protecting the livelihoods of farmers and maintaining the abundance of our food system.

Our Philosophy:
The last few decades of industrialization in animal agriculture have led to an unprecedented period of abundance in our food system. More people than ever have access to a practically unlimited supply of affordable, safe, and nutritious animal protein.

Yet this abundance hasn’t come without costs. Most people in our society care about the welfare of animals, and polls consistently show that Americans want animals on farms to be handled respectfully and responsibly. Yet when informed of practices that are commonplace on industrial farms, a vast majority of people express discomfort. Peoples’ assumptions and expectations around animal welfare are often disappointed by the realities of how animal agriculture currently works.

As a result, our society has had to start grappling with how to navigate the tradeoff between maintaining a safe, affordable, nutritious supply of animal protein, and maintaining the respect and care that everyone believes animals deserve. Heated debates have started within businesses, in our government, and in the media. With vociferous advocates on both sides, the conversation has become polarized, being too often framed as activists versus farmers, welfare versus affordability. 

We believe that the best solution is not to choose either animal welfare or an abundant food supply, but to leverage technology to have both.

The Lessons of Climate Tech:
The challenge of climate change is remarkably similar to the challenge of animal welfare. To use the language of economists, both are unpriced externalities: unplanned consequences of industrialization whose costs are not directly paid by producers or consumers, and hence are not inherently incentivized to be improved. No one wants the climate to change, yet it happens anyways. Similarly, no one wants a farm animal to be treated poorly, yet it happens anyways.

When it comes to climate change, the most promising practical solutions are technologies like solar panels, electric vehicles, improved batteries, and carbon capture. These technologies are powerful because they eliminate tradeoffs - they allow us to maintain the prosperity brought about by economic growth, while simultaneously mitigating the harms of climate change. 

Despite the similarities with the climate space, technology is an under discussed and underinvested in as a solution to animal welfare. Information is often difficult to impossible to find, and few champions actively push solutions forward. 

Our mission is to change this. Instead of continuing to grapple with how much we as individual consumers or business are willing to personally sacrifice for animal welfare, we can use technology to eliminate the tradeoff. By expanding what’s possible, technology allows us to preserve the abundance brought about by industrialized animal agriculture, while simultaneously bringing animal welfare in line with the expectations and demands of the modern consumer. 

Our Work:
Innovate Animal Ag was founded with the goal of helping companies develop and commercialize technologies that help meet the expectations and demands of the modern consumer around animal welfare. We do this by:
- Promoting technology as a practical solution to animal welfare
- Conducting research on cutting edge, science-backed, technologies in animal agriculture, then creating resources for businesses, policymakers, and the media
- Directly supporting the companies developing and implementing the most promising technologies, such as in-ovo sexing

Innovate Animal Ag

Allies Against Slavery builds platforms and partnerships that accelerate data-driven solutions to human trafficking. 

Human trafficking is a hidden problem that thrives in the shadows of society. Myths and misconceptions are pervasive, and data is unreliable. As a result, victims aren’t identified, traffickers aren’t prosecuted, and solutions aren’t data-informed or well-coordinated.

But that is changing. Allies Against Slavery harnesses data to illuminate and eradicate human trafficking. Our tools help allies in the fight to identify victims, coordinate care, and take informed action. 

Our vision is clear: to ensure that every community across the United States has the data it needs to combat and prevent human trafficking. But we cannot achieve this vision alone. We need to leverage innovative, data-driven solutions and forge crucial partnerships to shine a light on trafficking and build a future where freedom and dignity are secured for all. We invite you to join us in this important mission.

Allies Against Slavery

Sage builds tools to make sense of the future. Our projects include Fatebook and AI Digest.

Sage builds tools to make sense of the future. Our projects include:

- [AI Digest](https://theaidigest.org/): Visual explainers on AI capabilities and their effects
- [Fatebook](https://fatebook.io/): The fastest way to track your predictions
- [Quantified Intuitions](https://www.quantifiedintuitions.org/): Practice assigning credences to outcomes with a quick feedback loop

Sage Future

Founders Pledge is a global nonprofit empowering entrepreneurs to do the most good possible with their charitable giving. 

Maximize your philanthropic impact with Founders Pledge. We empower a global community of over 2,100 members, equipping them with everything needed to give effectively: from evidence-led research and expert advice on the world's most pressing problems to comprehensive infrastructure for seamless global grant-making, and a powerful network for collaboration. Together, we've already channeled over $1.5 billion to high-impact causes globally, tackling critical issues like climate change, global health, and emerging existential risks. 

When you donate through every.org today, you're joining this proven movement, and our unique funding model ensures 100% of your contribution goes directly to charity, as our operational costs are generously covered by a dedicated community of philanthropists.

Donate this Giving Season and we'll match your donation up to a value of $750,000, until Dec 31.

Founders Pledge

Communicating the best research and data to understand big global problems and make progress against them

Poverty, disease, hunger, climate change, war, existential risks, and inequality: The world faces many great and terrifying problems. Our World in Data focuses on communicating the best research and data that helps us understand and find solutions to the world’s largest problems.


Our World in Data publishes an open-access publication where users can understand the state of the world today, where we are making progress and where we are falling behind. Through interactive data visualizations we can see how the world has changed; by summarizing the scientific literature we can understand why. We cover everything from global poverty to natural disasters, education and health, democracy; we have over 13,000 charts across hundreds of topics.


Our World in Data is free, open-source and provided as a public good. It has millions of users every month, and is cited in research and media across the world every day. This allows millions of people to understand the large problems the world is facing, and how we can solve them.

Our World in Data

Pediatric malnutrition treatment – reimagined for scale.

Taimaka has reimagined pediatric malnutrition treatment to make it **more cost-effective and scalable**. We’ve developed a malnutrition treatment model that is:

1. 53% cheaper than legacy approaches and:
2. Leverages digitally-enabled community health workers (CHWs) to deliver care to the most vulnerable communities. 

So far, we’ve used our model to treat 6,000+ children out of existing government hospitals in northeastern Nigeria with world-class recovery rates of 95%+. Our track record has led charity evaluators like [Founder’s Pledge](https://www.founderspledge.com/funds/global-health-and-development-fund) to identify us as one of the most cost-effective nonprofits in global health, with a [cost-per-life saved of $1,644](https://docs.google.com/spreadsheets/d/16czhbk2xjA1EkhQxebnTV_49cwVC9XYFE23Jal2Yhu4/edit#gid=0). Over the next five years, we’re on track to expand our program to treat tens of thousands of children, while helping governments revamp their outdated programs so that they can double the number of children they reach. 

Read more at taimaka.org. 

Taimaka

Strengthening democracy by preparing all students for civic participation.

The DemocracyReady NY Coalition is the premier statewide force for civic education, with diverse, intergenerational leadership, a broad,  committed roster of members, and a strong track record of accomplishments. 

Our goal is to ensure every New York school provides **equitable, high-quality civic learning opportunities from pre-K through grade 12**, so all students graduate from high school ready for civic participation in college, career, and community life.

We work collectively to 

- **Raise awareness** about every student’s right under the state constitution to an education that prepares them for civic participation.
- **Strengthen investment**, **policy, and practice** to help students develop the knowledge and skills they need to engage effectively in civic and political life, today and in the future​. 
- **Eliminate inequities** in access to quality P-12 civic learning opportunities.
- **Mobilize** youth, families, educators, researchers, advocates, policymakers, and philanthropy to work collectively toward these goals.

DemocracyReady NY activities include

- Leading [research](https://democracyreadyny.tc.columbia.edu/resources/) and advocacy to advance access to high quality civic education for all students.
- Sponsoring [New York Civic Learning Week](https://democracyreadyny.tc.columbia.edu/activities/) and our annual Summit on Civic Readiness.
- Supporting a [dynamic statewide cohort of high school and college students ](https://youtu.be/CDD2kgcU7Vk?si=LACKnr0vedS6BvAE)
- Working with the national [CivxNow](https://civxnow.org/) coalition to secure federal commitments for civic education and to support other state efforts.

Founded in 2018 at the Center for Educational Equity at Teachers College, DemocracyReady NY became an independent organization led by Jessica R. Wolff and Nan Eileen Mead in 2025. 

DemocracyReady NY

We are a think tank dedicated to figuring out the best ways to make the world a better place.

Rethink Priorities is a think-and-do tank that informs nonprofits, funders and policymakers about how to most effectively improve the lives of humans and animals—both now and in the future.

Through rigorous analysis and strategic action, we identify high-leverage interventions across animal welfare, global health and development, and other neglected but promising areas. We maintain the highest standards of rigor while equally valuing curiosity and open-mindedness, working to drive evidence-based change where it's needed most.

If you'd like to support one of our fiscally sponsored projects (e.g. Epoch), you can give via Every.org, and let us know how to allocate your gift at info@rethinkpriorities.org.

Rethink Priorities

The AI Futures Project is a nonprofit research organization working to research and understand the trajectory of AI development

The **AI Futures Project** is a 501(c)(3) nonprofit research organization. We have developed a scenario forecast detailing the development of artificial general intelligence (AGI) and artificial superintelligence (ASI). Based on our research, we’ve come to believe that we might cross the thresholds to AGI and ASI within just a few years—and that plausible outcomes include unprecedented concentration of power, global catastrophe, or progress and flourishing.

The world is not ready for such a radical transformation. We hope to help policymakers, AI companies, AI entrepreneurs, AI safety researchers, and the general public to make sense of what’s coming, so they can take action and steer us in a better direction. In addition to our scenario forecast, we are developing [policy recommendations](https://time.com/collection/time100-voices/7086285/ai-transparency-measures/) and tabletop exercises (wargames) for decisionmakers.



AI Futures Project

Spritely Institute builds, researches, and standardizes networked technology which put people and communities first.


Centralized social media is harmful to society. We are building a gatekeeper-free decentralized system. Our mission is “social media done right”, to put people in control of their own identity and build the technology that would enable a shift to collaborative and intentional security models prioritizing active consent. To accomplish this, we will build a new architecture for the internet: removing the necessity of client-server architecture, replacing it with a participatory peer-centric model.

Spritely’s technology is being released as free and open source software aiming for multiple programming language implementations and eventual open standardization. All of our work, ranging from decentralized identity, peer-to-peer user agents, decentralized social networks, encrypted and portable storage, and distributed object programming infrastructure is being built to enable a gatekeeper-free path where users and content are not tied to a specific server.

Spritely Networked Communities Institute

Delivering unconditional cash directly to the world's poorest households via secure mobile transfers. 

Since 2009, GiveDirectly has delivered more than $1 billion in unconditional cash transfers directly into the hands of 2+ million people living in poverty. These one-time cash transfers allow recipients to invest in what they need most and have been shown to improve their earnings, children’s school attendance, health, nutrition, and mental well-being.
 
GiveDirectly uses government data to target villages where most or all residents are living in extreme poverty, defined by the World Bank as earning under $3/day. In-country GiveDirectly staff enroll each household in a village to receive a large lump sum transfer of \~$1,000 USD using mobile money. Recipients can then use the funds to invest in what they need – whether it’s on starting a business, education, repairing their home, healthcare, livestock, or anything else.
 
GiveDirectly also uses rigorous experimental research (including randomized controlled trials) to measure the impact of their cash programs, answer public policy questions, and generate evidence on key design and implementation questions.

GiveDirectly

Developing the roadmap for a sustainable, secure, and just global protein supply 🧫🌱


Check out what your support makes possible at gfi.org/your-impact. 

The Good Food Institute (GFI) is a global network of nonprofit organizations developing the roadmap for a sustainable, secure, and just protein supply. Industry alone will not meet this challenge at the scale or speed we need. GFI is accelerating the transformation of the food system by identifying solutions and mobilizing resources to make alternative proteins the default way meat is made.

GFI is a network of nonprofits around the world strategically based in the most critical economies for alternative protein advancement. In Asia, Europe, Brazil, India, Israel, and the U.S., GFI’s teams are mobilizing the international community to use markets and technology to replace harmful practices with ones that are better for the climate and biodiversity, for food security, and for global health.

GFI’s Focus
As a nonprofit, GFI is uniquely positioned to accelerate the transition to alternative proteins by focusing on three programmatic priorities:

-Cultivating a strong scientific ecosystem | GFI’s science and technology teams map out the most neglected areas that will allow alternative proteins to compete on taste and price. GFI meets these challenges by developing open-access research and resources, educating and connecting the next generation of scientists and entrepreneurs, and funding research that benefits alternative protein development across the sector. 

-Influencing policy and securing government funding | GFI’s policy teams ensure that alternative proteins are a part of the policy discussion around climate change mitigation and global health. In every region where GFI has a presence, teams advocate for government funding and incentives to transition to alternative proteins and are paving the way for the approval of novel proteins such as cultivated meat.

-Ensuring industry prioritizes alternative proteins | GFI’s corporate teams are creating a transformation of our global meat supply. GFI works to replicate past market transformations by showing companies of all sizes, from startups to multinational corporations, how alternatives to animal products can be profitable while meeting environmental, social, and governance goals.

Reimagining meat
The very real threats of climate change, global food insecurity, antibiotic resistance, and pandemics require us to imagine a different future of food. Alternative proteins are the solution that will securely and sustainably feed the world.

GFI’s global community of scientists, policy experts, and corporate specialists are creating a world where alternative proteins are no longer alternative.



The Good Food Institute

The Top Charities Fund supports the highest-priority funding needs among our top charities.

We find and recommend outstanding giving opportunities and publish our research to help donors give more effectively and with greater confidence.

All donations here support our Top Charities Fund. Donations to the Top Charities Fund are granted on a rolling basis to support cost-effective funding opportunities at our top charities. We use our latest research to grant the funds to the top charity (or charities) where we believe they’ll do the most good.

Learn more and view past grants at https://www.givewell.org/top-charities-fund


Photo caption: At health centers in Sierra Leone supported by Helen Keller Intl, mothers who bring their children in for twice-yearly vitamin A supplemention can also receive comprehensive counseling about birth control options that are available to them free of charge. Combining family planning and children's healthcare services benefits both mother and child. 2019.

Top Charities Fund

We search for the charities that save or improve lives the most per dollar.

Our goal is to produce the world's top research on where to give. Free, for everyone.

We recommend a small number of charities that do an incredible amount of good. 

If you would like to donate to our giving funds or individual top charities, please see our projects below. You can donate here or on the Unrestricted Fund page below to make an unrestricted gift to GiveWell to support the full spectrum of our grantmaking and underwrite our ability to continue doing what we do.

GiveWell

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1873740264

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We are a nonprofit, so instead of charging fees we rely on the generosity of donors like you.

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Mersal Foundation for Charity and Development

Mersal Foundation for Charity and Development

Zig Software Foundation Inc

Mersal Foundation for Charity and Development

ConnectMyVariant

Mersal Foundation for Charity and Development

Research