The Zig compiler and toolchain is tech the world needs, made in the way the world needs.

Hearing about this on Sam Harris's Podcast Making Sense made it clear that I should be donating too.

Good nutrition helps you avoid many health issues. An ounce of prevention works.

Zig is a general-purpose programming language and toolchain for maintaining robust, optimal, and reusable software.

The Zig Software Foundation is a non-profit corporation founded in 2020 by Andrew Kelley, the creator of Zig, with the goal of supporting the development of the language. Currently, the ZSF is able to offer paid work at competitive rates to a small number of core contributors. We hope to be able to extend this offer to more core contributors in the future.

Zig Software Foundation Inc

We match donations to any charity you choose while introducing you to super-effective charities. Learn more: GivingMultiplier.org

[**Giving Multiplier**](https://givingmultiplier.org) is a research project created at Harvard University that adds matching funds to any charity of your choice while introducing donors to highly effective charities recommended by experts.

*Resources:*

- [Make a donation that gets matched](https://givingmultiplier.org)
- [Become a matching funder](http://givingmultiplier.org/matching) (Donations made on this page will also go toward our matching system.)
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Questions? Email us: **info@givingmultiplier.org**

Giving Multiplier

Dedicated to inspiring and preparing youth for successful, thoughtful, and ethical engagement in STEAM and related professions.

To inspire lifelong engagement and ethical leadership in science, technology, engineering, arts, mathematics, and related professions through its proven educational model for mentoring, challenging, and motivating students. By building communities among students, teachers, and professionals, NYSAcademy programs complement, broaden, and enhance the traditional school curriculum leading to careers in science, technology, engineering, arts, mathematics, and related professions.

National Youth Science Academy

Developing the roadmap for a sustainable, secure, and just global protein supply 🧫🌱


Check out what your support makes possible at gfi.org/your-impact. 

The Good Food Institute (GFI) is a global network of nonprofit organizations developing the roadmap for a sustainable, secure, and just protein supply. Industry alone will not meet this challenge at the scale or speed we need. GFI is accelerating the transformation of the food system by identifying solutions and mobilizing resources to make alternative proteins the default way meat is made.

GFI is a network of nonprofits around the world strategically based in the most critical economies for alternative protein advancement. In Asia, Europe, Brazil, India, Israel, and the U.S., GFI’s teams are mobilizing the international community to use markets and technology to replace harmful practices with ones that are better for the climate and biodiversity, for food security, and for global health.

GFI’s Focus
As a nonprofit, GFI is uniquely positioned to accelerate the transition to alternative proteins by focusing on three programmatic priorities:

-Cultivating a strong scientific ecosystem | GFI’s science and technology teams map out the most neglected areas that will allow alternative proteins to compete on taste and price. GFI meets these challenges by developing open-access research and resources, educating and connecting the next generation of scientists and entrepreneurs, and funding research that benefits alternative protein development across the sector. 

-Influencing policy and securing government funding | GFI’s policy teams ensure that alternative proteins are a part of the policy discussion around climate change mitigation and global health. In every region where GFI has a presence, teams advocate for government funding and incentives to transition to alternative proteins and are paving the way for the approval of novel proteins such as cultivated meat.

-Ensuring industry prioritizes alternative proteins | GFI’s corporate teams are creating a transformation of our global meat supply. GFI works to replicate past market transformations by showing companies of all sizes, from startups to multinational corporations, how alternatives to animal products can be profitable while meeting environmental, social, and governance goals.

Reimagining meat
The very real threats of climate change, global food insecurity, antibiotic resistance, and pandemics require us to imagine a different future of food. Alternative proteins are the solution that will securely and sustainably feed the world.

GFI’s global community of scientists, policy experts, and corporate specialists are creating a world where alternative proteins are no longer alternative.



The Good Food Institute

High quality medical services for marginalized groups in Cairo and the region.

Mersal Foundation for Charity and Development is a non-profit organization that serves in the health field and works on providing all types of healthcare with high quality to whoever is in need.

**Vision**
To be the number one medical organization in Egypt and the Arab region and proactive in ensuring the right in healthcare for the marginalized groups and those who are in need the most.

**Message**
Working on analyzing and filling the gaps of the healthcare system to provide high quality medical services on the basis of equality and dignity through enabling a charitable healthcare system for whoever cannot afford it, as well as contributing to the development of the health sector.

**Objectives**  

- Providing medical services to whoever deserves them regardless the cost or for how long they will be needed.
- Spreading medical awareness in all the places it serves in.
- Achieving sustainability in funding its activities Core Values.
- Privacy: Mersal ensures the patient's eligibility to receive its services without hurting their dignity or exposing them to any kind of embarrassment.
- Healthcare With No Discrimination: Mersal is an open arm to all patients with no discrimination whatsover; whatever religion, nationality, color, or language, all patients in need are welcomed to receive the organization services.
- High Quality: Mersal provides all types of medical services in the highest possible quality through its network of specialized medical personnel.
- Credibility and Transparency: Mersal announces the size and sources of its fund as well as its administrative and medical expenditures, The foundation financial reports and annual budgets are available through several outlets through which any person can explore how resources are managed. Mersal believes in the importance of being specialized in specific fields and its early choice was the healthcare services.

In the past six years, the organization registered over 25,000 patients from 27 provinces.  Mersal has been seeking to enable access to its services all over the country. And the dream of helping those who are in need whoever they are and whatever the cost and time is still alive, Mersal has worked over the past six years on getting close to its patients throughout their treatment journey.

Mersal Foundation for Charity and Development 

Sentinel transforms pandemic prevention and response through cutting-edge technology, global collaboration, and local empowerment.

Infectious disease outbreaks have caused more illness, death, and economic loss than any other crisis in history. Pathogens kill millions of people each year and hit the most vulnerable communities the hardest. They go further—exposing and exploiting the deepest cracks in our societies and the risks are rising. 

 The forces driving pandemics are accelerating. Climate change is increasing human exposure to pathogens through animals and insects. Habitat encroachment and industrial agriculture are raising the risk of spillover. Global trade and travel speed disease spread, while conflict and instability weaken health systems. New biotechnologies pose engineered threats that current systems cannot detect. Over the past decade, the number of epidemics has grown by 20% worldwide. Between February and June 2025 alone, more than 70 outbreaks were reported across Africa. Yet global readiness is faltering. In the past year, U.S. investments in frontline health systems and disease surveillance have been sharply reduced. Funding cuts have disrupted networks and delayed the deployment of critical tools, especially in regions most vulnerable to outbreaks. Health programs across West and Central Africa now face rising threats with fewer resources and limited external support, leaving the world more exposed- with some experts estimating the probability of a pandemic in the next decade to exceed one in four.
 
Amid these mounting challenges, we stand at a historic moment of possibility. Sentinel, a pandemic early warning prevention and response program, is built to meet this moment: a locally led, technology-enabled model for proactive public health, integrating diagnostics, data, and training to stop outbreaks before they spread. 

Sentinel is an outbreak surveillance framework, designed to detect pathogenic threats in real-time and prepare the global community to stop diseases before they spread. It brings advanced science to the frontlines through a next-generation pandemic prevention system built around three core pillars. DETECT delivers rapid diagnostics and genomic surveillance. CONNECT integrates laboratory, clinical, and genomic data into real-time insights. EMPOWER invests in training, infrastructure, and institutional capacity so countries can lead their own outbreak responses.

DETECT: Timely diagnostics and sequencing are essential for early outbreak detection and effective response. Yet these capabilities remain limited in many LMICs, even for high-priority pathogens like Lassa, Ebola, and Marburg. Too often, health systems act only after outbreaks are widespread, costing precious time and lives. Sentinel’s DETECT pillar delivers speed, affordability, and accessibility through a tiered approach to diagnostic design and implementation.

CONNECT: Fragmented systems delay response and allow outbreaks to spread unchecked. When data are siloed, public health leaders lose time and visibility, undermining containment efforts. In contrast, integrated systems support faster, more effective action. Sentinel’s CONNECT pillar builds the digital backbone for outbreak response. Through interoperable dashboards and analytic platforms, it streamlines data flow, strengthens each stage of detection, analysis, and control, and enables real-time decision-making.

EMPOWER: Building local leadership and scientific capacity is central to Sentinel’s mission. Although over 60% of emerging infectious diseases originate in Africa and Asia, fewer than 10% of African countries had genomic surveillance at the start of COVID-19. Africa faces a shortfall of more than one million health workers, including critical gaps in genomics and data science. Sentinel’s EMPOWER pillar builds sustainable, locally led outbreak response by investing in people and communities. It enables local experts to detect and respond early with solutions grounded in context, shortening the path from innovation to public health practice and building resilient systems from within.

The foundation for Sentinel was laid over two decades through a 20-year partnership between Prof. Christian Happi, a Nigerian infectious disease expert, and Prof. Pardis Sabeti, a U.S.-based computational geneticist. Over the years this collaboration has established operational programs in Nigeria and Sierra Leone that connect health workers in rural clinics and hospitals with national and international public health leadership. **To date more than 3,000 public health workers from 53 of 54 countries in Africa** have been trained through Sentinel’s approach.

Sentinel-supported teams have enabled early detection and rapid response to Marburg, mpox, Lassa, dengue, and COVID-19, providing critical data to inform government action. 

COVID-19: Sentinel rapidly expanded genomic and diagnostic capacity across Africa, establishing pipelines with national partners. In March 2020, IGH sequenced Africa’s first SARS-CoV-2 genome within 72 hours of sample receipt. Sentinel supported testing for over 30 million people, deployed SHINE and CARMEN technologies, and led genomic surveillance in 26 countries. This work helped identify one of the first globally recognized variants of concern. Sentinel also trained scientists from 53 African countries, strengthening long-term preparedness. The Sentinel team also led one of the largest diagnostic and sequencing centers in the U.S. and supported global data sharing and informatics efforts.

Mpox: In 2023, Sentinel traced an mpox outbreak in Nigeria to oil workers in Rivers State, guiding the NCDC’s targeted vaccination strategy. Sentinel also hosted a three-week genomics bootcamp that trained regional professionals in real-time sequencing and analysis. Genomic data revealed sustained human transmission of the West African subtype, with signs of adaptation and rising pandemic potential. When an outbreak emerged in Sierra Leone in 2024, local public health teams, supported by Sentinel, initiated sequencing and shared real-time data. Analysis identified a new highly transmissible G.1 variant spreading beyond previously affected groups. Sentinel tools and team members remain central to guiding the national response.

 Marburg: In 2024, Sentinel supported the Rwandan government during a Marburg outbreak in Kigali. IGH provided outbreak reconstruction and real- time sequencing, while Prof. Happi co-chaired the national scientific response. The outbreak was contained at 66 cases, with the case fatality rate reduced to 22%, far below historical averages.

Building off of these successes, Sentinel is poised for its next phase: deepening national integration, expanding its reach, and advancing a globally transferable model for pandemic prevention. We will achieve full national implementation in Sierra Leone and move toward this in Nigeria, embedding surveillance into national systems and incorporating a One Health approach that addresses climate-linked and zoonotic threats. Expansion will continue to Senegal, Rwanda, and the Democratic Republic of Congo, where strong partners and readiness are in place. In parallel, we are globalizing Sentinel’s tools, data platforms, and training programs to create a lasting framework for pandemic prevention.

Sentinel will help millions benefit from earlier detection, faster response, stronger systems, and a globally connected early warning network. This is the moment to transform pandemic prevention and safeguard global health security for generations to come.

There will be another pandemic virus in our lifetimes—it may already be here, but our work is about more than stopping disease outbreaks. By empowering people and equipping them with the tools, the system, and the knowledge needed, we create strong and resilient communities for generations to come. Sentinel is about partnership, solidarity, and most importantly, hope!

That's why we believe that with you, we can make an impact.

Sentinel 

Help preserve the Shulgin legacy and build a global community dedicated to scientific, therapeutic, and spiritual insight.

The Shulgin Foundation honors the revolutionary legacy of Ann and Sasha Shulgin while building a vibrant future for psychedelic science, healing, and community.

From an unassuming 200-square-foot lab in Lafayette, California, Sasha Shulgin created over 150 novel psychedelic compounds, including MDMA, while Ann pioneered therapeutic frameworks that continue to guide modern psychedelic therapy. Their historic Farm—a gathering place for four decades of psychedelic research and community—stands as both a monument and a living laboratory.

Today, the Foundation is preserving this irreplaceable heritage site while fostering a global community dedicated to scientific discovery, therapeutic advancement, and spiritual exploration. Through educational programs, archival preservation, and community gatherings, we are carrying forward the Shulgins' vision of responsible inquiry and compassionate care.

Your tax-deductible donation supports:

- Preserving the historic Shulgin Farm property
- Creating accessible psychedelic education
- Archiving invaluable research materials
- Building community across generations of researchers and healers

Join us in honoring the past while creating the future of psychedelic science and healing.

Shulgin Foundation

Coordinating hemispheric action against screwworm, a flesh-eating parasite causing billions in losses and immense animal suffering

**The screwworm barrier has collapsed. We have 12-18 months to coordinate a hemispheric response. That's where we come in.** 

In September 2025, screwworm was detected in Mexico, 70 miles from the US border. The Panama biological barrier that protected North America for two decades has failed. USDA just announced a $100M innovation fund. For the first time in a generation, continental control and eradication is politically viable.

**The Problem**

The New World Screwworm is a flesh-eating fly that lays eggs in open wounds. The larvae burrow into living flesh, consuming the host from inside. Infected animals experience excruciating pain, stop eating, and die slowly over days to weeks. This parasite occasionally infects humans too.

This happens to hundreds of millions of animals every year across South America. The annual economic cost is $3.5-7 billion in livestock losses alone. The suffering inflicted on wild animals is unquantified but likely orders of magnitude larger.

Screwworm was eliminated from the US and Central America using sterile insect technique between the 1960s and early 2000s. South America was left behind because of coordination failures and lack of international support.

**Why Now**

The barrier collapsed. Screwworm is moving north toward US agricultural interests, creating unprecedented political will. Without coordination, countries will act defensively. South America remains infested, the US spends billions on perpetual containment, and hundreds of millions of animals continue to die in agony.

New technologies like gene-drive-enhanced sterile insect technique could make eradication faster and cheaper than ever before.

**What We Do**

Screwworm Free Future ("Futuro Libre de la Bichera") coordinates the scientific, economic, and political work needed for continental elimination. We are the only organization working full-time on screwworm eradication advocacy.

Since founding in 2024, we've established relationships with agricultural officials across South American countries, met with USDA, published in the Washington Post, and secured partnerships with leading researchers. Our Executive Director brings a track record of mobilizing funding and policy momentum for neglected disease areas and is supported by a team and volunteers across the Americas. 

Our theory of change is simple: eradication requires multiple countries to commit simultaneously. 

We evaluate the viability of continent-wide eradication approaches, build relationships with decision-makers across the Americas, perform high-impact research, and facilitate coordination where currently there is little.

**Your Impact**

Accelerating eradication by one year would spare hundreds of millions of animals while generating billions in economic value. We believe our cost-effectiveness is on par with top animal welfare interventions.

This is the most important moment for screwworm elimination in 20 years. Your support helps us seize this narrow political window before it closes.

Screwworm Free Future / Futuro Libre de la Bichera / Futuro Livre de Bicheira

Support our mission to ensure trustworthy and safe AI at Apart Research.

We are active contributors and enablers of AI safety research. Our mission is to minimize the risks posed by large-scale AI applications to society. To this end, we conduct research to develop safer AI and nurture talent for AI safety research roles. We organize international research sprints focused on safety topics and support talented researchers in transforming their work into fully published articles.

Apart Research

We make a firm commitment to education, research and social debate to support talent in order to make a positive impact on society

Support Education!
 
Esade is a global institution structured as a Business School, a Law School, and an Executive Education area. Esade is a global academic institution known for the quality of its education, its international outlook, and its focus on holistic personal development. Esade has strong ties to the business world. 

"Do Good. Do Better": This encompasses our reason to exist and our purpose. It is our pledge to bring meaningful change by focusing on innovation and social commitment. Esade's academic activity encompasses three main areas: 

- Education: ESADE applies a unique and innovative learning model based on the internalisation of values and the development of professional and executive competences. 

- Research: ESADE generates new knowledge that helps to improve the dynamics of organisations, businesses and the practice of law.

- Social Debate: ESADE is a platform where people can gather and discuss important issues with the aim of improving society.

Esade Foundation

Spritely Institute builds, researches, and standardizes networked technology which put people and communities first.


Centralized social media is harmful to society. We are building a gatekeeper-free decentralized system. Our mission is “social media done right”, to put people in control of their own identity and build the technology that would enable a shift to collaborative and intentional security models prioritizing active consent. To accomplish this, we will build a new architecture for the internet: removing the necessity of client-server architecture, replacing it with a participatory peer-centric model.

Spritely’s technology is being released as free and open source software aiming for multiple programming language implementations and eventual open standardization. All of our work, ranging from decentralized identity, peer-to-peer user agents, decentralized social networks, encrypted and portable storage, and distributed object programming infrastructure is being built to enable a gatekeeper-free path where users and content are not tied to a specific server.

Spritely Networked Communities Institute

Founders Pledge is a global nonprofit empowering entrepreneurs to do the most good possible with their charitable giving. 

Maximize your philanthropic impact with Founders Pledge. We empower a global community of over 2,100 members, equipping them with everything needed to give effectively: from evidence-led research and expert advice on the world's most pressing problems to comprehensive infrastructure for seamless global grant-making, and a powerful network for collaboration. Together, we've already channeled over $1.5 billion to high-impact causes globally, tackling critical issues like climate change, global health, and emerging existential risks. 

When you donate through every.org today, you're joining this proven movement, and our unique funding model ensures 100% of your contribution goes directly to charity, as our operational costs are generously covered by a dedicated community of philanthropists.

Donate this Giving Season and we'll match your donation up to a value of $750,000, until Dec 31.

Founders Pledge

Created in 1997, the Fondation des Ponts supports the development of the Ecole des Ponts ParisTech and its students.

Excellent research and educational innovation 
 
Created in 1997 on the initiative of 11 major French companies, as well as the association of former ENPC students (AAENPC), the Fondation des Ponts supports the development of the Ecole des Ponts ParisTech and its students. École des Ponts ParisTech, created in 1747 under the name École Royale des Ponts et Chaussées, is a higher education establishment that trains engineers to a high level of scientific, technical and general competency. 

Recognized as a public utility, the Fondation des Ponts supports the development of the École des Ponts ParisTech by financing a whole series of projects that can be grouped according to 6 major themes:  
- Support research and educational innovation. 
- Support students, promote diversity, encourage excellence. 
- Increase the School's international reach to attract excellent teachers, researchers and students.  
- Helping startups created by students 
- Allow the School to have the facilities and equipment required to support its development. 
- Promote the historical and scientific heritage of the School. 

Visit our website:  http://www.fondationdesponts.fr/

Fondation de l'École nationale des ponts et chaussées 

FAR.AI’s mission is to ensure AI systems are trustworthy and beneficial to society. 

We incubate and accelerate research agendas that are too resource-intensive for academia but not yet ready for commercialization by industry. Our research spans work on adversarial robustness, interpretability and preference learning.

FAR.AI

Phare Bio is using AI/deep learning to discover novel classes of antibiotics to address a looming crisis in antibiotic resistance.

Phare Bio is an ambitious social venture using novel AI and deep learning approaches to antimicrobial development in collaboration with Professor Jim Collins at MIT, a founder of the field of synthetic biology. Phare is a recipient of the Audacious Project, a collaborative funding initiative between TED and other non-profits to unlock social impact on a grand scale. 

The rapid evolution of antibiotic-resistant bacteria and a dwindling discovery pipeline have resulted in an antimicrobial resistance (AMR) crisis. Today, according to the Centers for Disease Control and Prevention, someone in the U.S. acquires a resistant infection every 11 seconds; every 15 minutes someone dies as a result of one. Covid-19 has only highlighted the urgency with approximately 15% of hospitalized patients suffering from bacterial co-infections. There is a critical need for new antibiotics, and yet, pharmaceutical and biotechnology companies have largely abandoned the space in favor of more lucrative markets. 

Phare Bio launched in 2020 to tackle this critical unmet need with the latest advances in machine learning to develop entirely novel antibiotics. Integrating world-class expertise and decades of experience in artificial intelligence (AI), bioengineering, and life sciences, Phare is targeting the world's most deadly pathogens, such as Acinetobacter and Pseudomonas, with the goal of developing seven novel classes of antibiotics in seven years. 

Phare Bio

Terra Praxis designs and implements strategies that leverage science, technology and energy innovation for a prosperous planet

We co-founded TerraPraxis to design and implement strategies that leverage science, technology and energy innovation for a prosperous planet. Our mission is to innovate and accelerate scalable, equitable solutions for unsolved areas of the climate challenge. 

Our special focus is on enabling high-impact rapid transitions for neglected parts of the decarbonization challenge. 

We work with an extensive global network to define, incubate and initiate scalable strategies that fulfil the twin missions of prosperity and decarbonization. 

Terra Praxis

Creative Commons (CC) stewards a universally accessible infrastructure for open knowledge, culture, and collaboration. 

Creative Commons is the global nonprofit organization behind the CC licenses and public domain tools, enabling the free and open distribution of otherwise copyrighted work. We give every person and organization in the world a simple and standardized way to grant copyright permissions for images, music, research, journal articles, educational resources, and cultural artifacts; ensure proper attribution; and allow others to copy, distribute, and make use of those works.

We've come a long way since we first got started in 2001. When Creative Commons was  founded, the internet was a budding universe with high potential, and platforms widely used today like Wikipedia and Google were only just taking off. CC’s founders were keen to ensure that, as the internet continued to grow, safeguards to knowledge, culture, and creativity were firmly in place, and the Creative Commons license suite was born.

Now more than ever, CC recognizes the urgent need for these licenses in advancing Better Sharing, key to preserving our global commons. As we look toward the next 20 years, CC seeks to fearlessly advocate for Open Knowledge to address the many challenges our global community faces today from the Climate Crisis and educational inequalities to the spread of "fake news" and barriers in access to cultural heritage.

Creative Commons

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founder @ camp.org, expa.com, uber.com & mix.com

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Zig Software Foundation Inc

National Youth Science Academy

Zig Software Foundation Inc

The Good Food Institute

Giving Multiplier

Mersal Foundation for Charity and Development

Research