In honor of my late grandfather Vladimir Bugo. May his soul rest in peace 

We provide cash incentives for childhood vaccinations. It’s one of the most cost-effective ways known to save lives.


New Incentives’ mission is to save lives in a way that does the **most good per dollar**.
Guided by evidence, we provide cash incentives to increase childhood vaccination rates.

- We [raise awareness](https://www.newincentives.org/blog-posts/awareness-activities) about the benefits of childhood vaccinations.
- We [provide cash incentives](https://www.newincentives.org/blog-posts/a-day-in-the-life-abubakar-aliyu-field-officer) at government clinics after children receive vaccinations.
- We [help improve the vaccine supply chain](https://www.newincentives.org/blog-posts/supporting-government-partners-with-vaccine-supply-efforts) to ensure enough vaccines are available at clinics.

Together, these efforts are proven to double vaccination rates and save lives.
Learn more about the [randomized controlled trial](https://www.newincentives.org/rct-results).

As of March 2024, New Incentives has reached more the 3 million infants in northern Nigeria.

New Incentives

We are a research hospital that treats patients in all medical disciplines, focusing on oncology, neurology, and diagnosis.

The Fondazione Casa Sollievo della Sofferenza – Opera di San Pio da Pietrelcina (transl. Home for the Relief of Suffering Foundation – Work of Saint Pio of Pietrelcina) is a not-for-profit research hospital located in the city of San Giovanni Rotondo (FG), in the Puglia Region, Southern Italy.
As per Canon 1303 §1 of the Code of Canon Law, it has public, canonical and civil legal personality; it is therefore subject to the supervision of the Holy See and, on its behalf, of the pro-tempore Cardinal Secretary of State. 
Many of the stages that have thus far marked the history of the Work of San Pio of Pietrelcina have been achieved thanks to the loving generosity of many benefactors who, sharing the mission indicated by San Pio da Pietrelcina, the relief of suffering, wanted to donate to his work.

HISTORY
The hospital was founded and inaugurated by Saint Pio of Pietrelcina on May 5, 1956 with a capacity of 250 beds. It took on the status of Provincial Hospital on 4 August 1971 and then of Regional General Hospital on 2 June 1980, thus becoming part of the Italian National Healthcare System. Since 16 July 1991, with a Decree of the Minister of Health and the Minister of University and Scientific Research, it has been a Research Hospital. Originally, the object of its scientific activity was limited to genetic and hereditary-familial diseases; subsequently, the Minister of Health, by the 5 December 2012 Decree, extended the research areas of its competence to "Genetic diseases, innovative therapies and regenerative medicine". Recently, on the occasion of the presentation of the research lines for the three-year programme of the Italian Research Hospitals 2022-2024, Casa Sollievo identified “Diagnostic acitivity, Neurology and Oncology” as its main research thematic areas, thus becoming a polythematic Research Hospital.

MISSION
The Foundation's mission is to provide health care and carry out research activities. In addition, the Foundation offers training activities for its personnel.
Around 2,750 people work at the Foundation.
The Foundation (hereinafter “CSS”) consists of three structures based in San Giovanni Rotondo: the hospital Casa Sollievo, the polyclinic Giovanni Paolo II, where outpatient activities are carried out, and the ISBReMIT research center for regenerative medicine (Institute for Stem-cell Biology, Regenerative Medicine and Innovative Therapies); and the Mendel Institute in Rome, where research and diagnostic activities are carried out. In San Giovanni Rotondo, it also owns and runs a retirement home for the elderly.
In addition, CSS owns 3 hospitality facilities where affordable accommodation is offered to hospitalized patients’ relatives who have to assist them; and another facility (Casa Zeni) where accommodation is offered free of charge to the parents of the little patients hospitalized in the oncology-hematology unit.
Moreover, the Foundation includes the Padre Pio Prayer Groups Centre, which was also founded by San Pio and coordinates the Padre Pio prayers groups throughout the world, according to the Founder’s wish that Prayers Groups live and testify the importance of prayer and pray for CSS.
Lastly, CSS publishes a monthly periodical and posts on the Foundation’s official channels on the web updates on its research and clinical activity and its spiritual activity and the teachings of the Founder.
The hospital offers assistance also to people from underdeveloped countries. 
Moreover, a free-of-charge shuttle service has been provided for many years to radiotherapy patients coming from Bari and surrounding cities (Southern Puglia).

THE CLINICAL ACTIVITY
CSS has around 756 beds, 38 medical and surgical inpatient units, 26 operating rooms, in addition to services, diagnostic and multi-specialist outpatient units.
In 2022, the hospital recorded over 30,000 hospitalizations and 870,000 outpatient performances. 
Regarding the advanced technological equipment, CSS has 1 "Da Vinci" surgical robot, 1 PET/CT device, 3 linear accelerators, 4 CT devices, 1 CT simulator for radiotherapy, 4 NMR equipment, 3 digital angiographs, 2 gamma cameras and a RIS/PACS system for the filmless management of the radiology department.
Furthermore, CSS hosts an Umbilical Cord Bank and a Human Milk Bank.
Recent Achievements
In addition to the many important activities carried out in CSS, 3 new units have been opened: 1. a new Emergency Room hosting an Observation and Assessment Ward; 2. an Hematopoietic Stem Cell Transplant Center. 3. an Sub-Intensive Geriatric Unit. 
CSS has also established a Stroke Unit, a Lung Unit, a Breast Unit, a Head and Neck Unit, and a Molecular Tumor Board to guarantee appropriate, quality and homogeneous procedures.
Future goals
Important technological investments have been planned for the years 2023-2025 in the following areas: oncology/nuclear medicine, diagnostic imaging, ICU, and surgery. 

THE RESEARCH ACTIVITY
The research activity is conducted in the Polyclinic, the ISBReMIT research center and at the Mendel Institute, for a total of 17 research groups.
Recent achievements
The consolidated experience of the staff working in CSS in the study of genetic diseases since 1991 and the continuous updating of technologies, instrumentation and genomics and post-genomics skills have made it possible to direct the research and clinical-assistance activity towards two complementary research lines: "personalized medicine - system biomedicine" and "regenerative medicine" based on the study of tumor stem cells and the use of normal stem cells.
The scientific fields in which the Institute is mostly involved in "personalized medicine" concern the identification of the genetic causes of rare diseases and the identification of diagnostic, prognostic and predictive markers in complex pathologies, including tumor pathologies. Regarding the identification of the genetic causes of rare diseases, we use the new next generation sequencing (NGS) technologies and the skills acquired by the bioinformatics unit, one of the first established at national level. In parallel, the Institute boasts a large collection of induced pluripotent stem cells (iPSCs), produced from patient fibroblasts, in which pathogenetic variants have been identified, and use the skills acquired in differentiating them into mature cells, in particular astrocytes, neurons and oligodendrocytes.
Regarding regenerative medicine, two important studies were conducted and concluded: a phase I trial on anti-Multiple Sclerosis therapy based on the use of human neural stem cells, approved by the Ministry of Health and the Italian Medicines Authority AIFA (EudraCT code 2015-004855-37); and a phase I/II trial on anti-glioma therapy with biological drugs (EudraCT code: 2016-001761-92). The results of these studies will published in prestigious international journals.
In 2015, the new ISBReMIT Regenerative Medicine Research Center was started. It is a cutting-edge structure in terms of conception and equipment in the field of translational medicine for genetic, degenerative and oncological diseases. The structure hosts, together with the highly technologically equipped laboratories, a cell factory and a laboratory for the production of biopharmaceuticals under Good Manufacturing Practice, i.e. for clinical use, including somatic stem cells and iPS, vectors for gene therapy and biomaterials.
It should be noted that CSS has recently become part of three Networks of the Italian Research Centers: since 2016 it has been an Ordinary Associate of Alleanza Contro il Cancro; since December 2018, of the National Research Network on Aging; and, finally, since March 2020 of the Neuroscience Network. Starting from 2022, CSS has been part of the European reference networks for rare and uncommon diseases (European Reference Networks - ERN), in particular ERN-SKIN on diseases of dermatological interest, and ERN ReCONNET on musculoskeletal diseases and pathologies of the connective tissue.
Researchers publish about 200 scientific articles in the most renowned journals (Science, New England Journal of Medicine, Nature Genetics) every year. They are engaged both as Principal Investigators and as partners in research projects in the biomedical field and ICT, obtaining funds from the EU (H2020 and FP7) and national or regional calls.
CSS is also a partner in Research and Innovation projects funded by private and public bodies, e.g. from the EU both under Horizon 2020 and Horizon Europe, in the field of digital transformation of healthcare. The main areas of involvement concern Assistive Robotics, Artificial Intelligence, Big Data generated by consumer devices, eHealth, Digital Therapies, the Internet of Things and Cybersecurity.
Future goals
Starting from the identification of the genetic causes of diseases, the goal is to develop advanced therapies to bring to the patient's bedside and tailored to him/her.
Furthermore, at the end of 2023, the phase II study "Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis: A multicenter, randomized placebo controlled and biological endpoints clinical Trial" (EudraCt 2018-002373-22) will be launched. This involves the use of neural stem cells on patients suffering from Amyotrophic Lateral Sclerosis.

CONCLUSION
Casa Sollievo della Sofferenza was born of the visionary mind of a poor friar, one of the most important, recent and internationally recognized and prayed Saints, Saint Pio of Pietrelcina, right after the II World War, in a poor corner of the Southern Italy of those times. 
CSS, by its Statutes, is a not-for-profit organization. All the good work that has been done until now for the sick has been possible thanks to the generosity of donors and to the public and private funds that have been collected through the hard work of the Foundation’s researchers and clinicians, thus contributing importantly to the care of citizens from Southern Italy and underdeveloped countries and to the world research.

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza - Opera di San Pio da Pietrelcina

High quality medical services for marginalized groups in Cairo and the region.

Mersal Foundation for Charity and Development is a non-profit organization that serves in the health field and works on providing all types of healthcare with high quality to whoever is in need.

**Vision**
To be the number one medical organization in Egypt and the Arab region and proactive in ensuring the right in healthcare for the marginalized groups and those who are in need the most.

**Message**
Working on analyzing and filling the gaps of the healthcare system to provide high quality medical services on the basis of equality and dignity through enabling a charitable healthcare system for whoever cannot afford it, as well as contributing to the development of the health sector.

**Objectives**  

- Providing medical services to whoever deserves them regardless the cost or for how long they will be needed.
- Spreading medical awareness in all the places it serves in.
- Achieving sustainability in funding its activities Core Values.
- Privacy: Mersal ensures the patient's eligibility to receive its services without hurting their dignity or exposing them to any kind of embarrassment.
- Healthcare With No Discrimination: Mersal is an open arm to all patients with no discrimination whatsover; whatever religion, nationality, color, or language, all patients in need are welcomed to receive the organization services.
- High Quality: Mersal provides all types of medical services in the highest possible quality through its network of specialized medical personnel.
- Credibility and Transparency: Mersal announces the size and sources of its fund as well as its administrative and medical expenditures, The foundation financial reports and annual budgets are available through several outlets through which any person can explore how resources are managed. Mersal believes in the importance of being specialized in specific fields and its early choice was the healthcare services.

In the past six years, the organization registered over 25,000 patients from 27 provinces.  Mersal has been seeking to enable access to its services all over the country. And the dream of helping those who are in need whoever they are and whatever the cost and time is still alive, Mersal has worked over the past six years on getting close to its patients throughout their treatment journey.

Mersal Foundation for Charity and Development 

Whole Child International is a nonprofit, international child protection and development organization founded in 2004. 

Whole Child International works collaboratively with local partners, governmental and non-governmental, to ensure that children receive the quality of care they need to grow into resilient, productive citizens, regardless of where they live.  We use an evidence-informed approach, drawing on cutting edge child development research, to train caregivers, child protection authorities, and government actors to ensure the entire child protection and development system is focused on ensuring positive outcomes for the most vulnerable children.  

Our work in Nicaragua and El Salvador produced statistically significant improvements in cognitive and social functioning, as well as weight- and height-for-age, without substantial changes to the material environment or their diets.  We change the behavior of the adults around the children to provide relationship-centered care and transform children's developmental trajectory.  Developmentally supportive care in childhood is associated with better educational, economic, health (physical and mental), and social outcomes later in life; that is, providing quality care for today's children helps reduce poverty, conflict, and social inequities in the future.  

Women and children are disproportionately affected by violence, climate change, and poverty; they are also key to disrupting these harmful cycles.  Our approach strengthens families, both biological and not, by equipping caregivers with the skills they need to care for their children's holistic needs, emotional, developmental, nutritional, etc.  We work with childcare centers and providers in low-income and high-violence areas to improve the quality of care available to children who might otherwise not have access to these services.  We especially work with women -- both caregivers and those working in the child protection system -- to develop their capacity as community leaders and models for positive change.   

At Whole Child International, we Embrace the Future.

Whole Child International

Our mission is to protect LGBTQ+ youth in Poland from the harms of homelessness and refugeehood. 

The Warsaw House Foundation's mission is to protect homeless and refugee  LGBTQ+ youth in Poland and provide them with the tools they need to live independently. Our inspiration was the  Ali Forney Center  (AFC)  n NYC, which is largest organization in the world offering support to homeless LGBTQ+ youth. We are honored that Carl Siciliano, the AFC's founder is on the board of the Warsaw House Foundation and works as an advisor. We place extra attention on HIV and STI education, support and prevention with the help of board member Dr. Joanna Kubica and the Smart Life Clinic in Warsaw.  After we took in our first LGBTQ+ youth to house on February 14th, 2023  we have been flooded with calls for housing and support from young people in need.  These are Polish Trans 18 year-olds from the Polish countryside in desperate need to escape their abusive and intolerant homes, young queer people with PTSD and untreated mental illness who need housing and support immediately, LGBTQ+ refugees from Ukraine and several young gay men from Iraq who suffered torture in their homeland, were detained and imprisoned at the Polish/Belarussian border for up to two years, and are now trying to build their lives in Poland.  We are also housing and supporting young LGBTQ+ people from Uganda and Egypt,  We are raising money to support the young people under our care, to house and feed them and pay for their medical needs and courses needed for them to start an independent life,  We are also raising money to hire staff (all of WH's work is now done by volunteers), to continue the renovation of our residential building and for short term emergency rentals.  We have a committed and professional team and a well planned strategy for both emergency and long term care.  Any help would be greatly appreciated!! We will be in regular contact if you'd like to hear of our progress and  if you'll be in Warsaw, we'd be delighted to meet with you personally and show you the work we do.

Warsaw House Foundation

Not for profit, founded as a 501C3 charity in 2006 in NYC. Providing Health, Education, and Empowerment opportunities.

Our cornerstone project was building East & Central Africa's 1st Public Children's Hospital.  Since opening in 2015, we have treated over 1.3 million kids. The impact does not end there, we have also constructed six public (free-to-attend) schools, a dairy project, a kids community house and more. We also run a vibrant Women's Empowerment Project focusing on agri-biz and domestic violence survivors.  Our latest major project is constructing the first children's cancer hospital in sub-Saharan Africa.

visit our Learn About Us page on shoe4africa.org

Shoe4Africa

We target opportunities where small investments can generate extraordinary impact and create lasting change.

There are many charities that address global poverty and suffering. 

With our Global Health & Development (GHD) **Catalytic Impact Fund**, we try to find the strategic pressure points where modest funding unlocks transformational change. 

By prioritizing these leverage points, we help donors maximize their impact in building sustainable, long-term solutions to global poverty and suffering — saving and improving as many lives as possible with each dollar.

What does catalytic impact look like?

- **We trigger systemic improvements**: We support investments that create new long-term infrastructure or increase the cost-effectiveness of existing systems.
- **We remove key bottlenecks**: We identify and remove barriers that stand in the way of accelerated impact.
- **We crowd in capital**: We provide early-stage funding that attracts substantial follow-on investment for cost-effective opportunities.

### Our Approach to Grantmaking

When evaluating potential grants, we consider several key points:

- **Counterfactual impact**. Our grants are designed to create meaningful outcomes that would not otherwise have happened. This means that you can rely on the Funds to create meaningful, real change, rather than just maintaining the status quo.
- **Impact-driven philanthropy**. This fund prioritizes the highest-impact solutions to challenges. We assess where the gaps are, which opportunities may be neglected by other funders, and where the biggest wins are in terms of making the biggest difference.
-  **The organization’s funding gap**. Not all organizations are set up to scale programs and some may not be able to productively absorb large amounts of unsolicited funding at any given point. We evaluate all potential grantees’ capacity for growth and consider how much money they could put to good use.
-  **Organizational strength**. Particularly with unrestricted funding, it’s important to have trust in the leadership and capacity of the organizations we support. We look at their track record of success and their transparency about failures as well as successes, and we only support those organizations which are exceptionally well run.
- **Time-critical opportunities and funding certainty**. Sometimes there are time-critical opportunities which require fast decisions. We will use the Fund to make grants that enable such short-term opportunities and stability for high-impact funding opportunities thereby increasing the impact compared to individual giving to specific organizations.

### Frequently-Asked Questions

**Can charities apply for money from the Fund?**

Founders Pledge reviews [requests for funding](https://www.founderspledge.com/requests-for-funding) from organizations, but does not guarantee we can fill funding requests.

**How frequently will you make grants from the Fund?**

In general, Fund Managers will review grantmaking decisions on a quarterly basis, based on the value of Funds and the available options for high-impact grantmaking. We may disburse funds outside of quarterly review dates if we become aware of a particularly promising and time-sensitive funding.

**How will my contribution be used?**

All funds are granted out — every dollar contributed to the Fund will be used to make grants directly to end-user organizations creating a real difference.

### More Questions?

To learn more about the Founders Pledge GHD Catalytic Impact Fund, please visit [founderspledge.com](https://founderspledge.com/funds/global-health-and-development-fund) or email the team at [funds@founderspledge.com](mailto:funds@founderspledge.com).

Founders Pledge: GHD Catalytic Impact Fund

YOU bring real, lasting social change in the Democratic Republic of Congo(DRC). Join us.

“Women are the first victims of war, but only they hold the unique key to peace.” – Julienne Lusenge 
 
 The Fund for Congolese Women (FFC)   supports women's grassroots organizations through financial and technical assistance.  FFC is unique - the only women-led grant-giving NGO in the entire DRC. We provide grants to local women-led organizations that are often in the most remote, difficult to reach areas.   Why? We are unshakable believers in local solutions to local issues.  We know that the brave women and girls working at the grassroots level have the solutions. We know that when women become agents of change, they benefit, their families benefit, their communities benefit. Since its inception in 2007, FFC has funded more than 386 projects throughout the Democratic Republic of Congo. We support projects focusing on eliminating sexual violence against women, delivering empowerment programs for women and girls, educating women about HIV/AIDS and reproductive health, and advocating for environmental justice and access to resources and land for women.  Generous individuals like you make our work possible.  Thank you! 
 
 
 Join the conversation and follow us on Twitter and like us on Facebook.

Fund for Congolese Women (FFC)

Phare Bio is using AI/deep learning to discover novel classes of antibiotics to address a looming crisis in antibiotic resistance.

Phare Bio is an ambitious social venture using novel AI and deep learning approaches to antimicrobial development in collaboration with Professor Jim Collins at MIT, a founder of the field of synthetic biology. Phare is a recipient of the Audacious Project, a collaborative funding initiative between TED and other non-profits to unlock social impact on a grand scale. 

The rapid evolution of antibiotic-resistant bacteria and a dwindling discovery pipeline have resulted in an antimicrobial resistance (AMR) crisis. Today, according to the Centers for Disease Control and Prevention, someone in the U.S. acquires a resistant infection every 11 seconds; every 15 minutes someone dies as a result of one. Covid-19 has only highlighted the urgency with approximately 15% of hospitalized patients suffering from bacterial co-infections. There is a critical need for new antibiotics, and yet, pharmaceutical and biotechnology companies have largely abandoned the space in favor of more lucrative markets. 

Phare Bio launched in 2020 to tackle this critical unmet need with the latest advances in machine learning to develop entirely novel antibiotics. Integrating world-class expertise and decades of experience in artificial intelligence (AI), bioengineering, and life sciences, Phare is targeting the world's most deadly pathogens, such as Acinetobacter and Pseudomonas, with the goal of developing seven novel classes of antibiotics in seven years. 

Phare Bio

One of GiveWell's top charities for the past several years, AMF provides anti-malarial bednets to people in need. 

From Givewell: 
What do they do? AMF (againstmalaria.com) provides funding for long-lasting insecticide-treated net (LLIN) distributions (for protection against malaria) in developing countries. (More)

Does it work? There is strong evidence that distributing LLINs reduces child mortality and malaria cases. AMF conducts post-distribution surveys of completed distributions to determine whether LLINs have reached their intended destinations and how long they remain in good condition. AMF's post-distribution surveys have generally found positive results but have some methodological limitations. (More)

What do you get for your dollar? We estimate that the cost to purchase and distribute an AMF-funded net is $4.95, or $4.65 excluding in-kind contributions from governments. The numbers of deaths averted and other benefits of distributing LLINs are a function of a number of difficult-to-estimate factors, which we discuss in detail below. (More)

Is there room for more funding? We believe that AMF is likely to be constrained by funding. We estimate that AMF could use up to an additional $37.8 million to support LLIN distributions that will occur between now and late 2023. 

AMF is recommended because of its:

Focus on a program with excellent evidence of effectiveness and cost-effectiveness.
Processes for ensuring that nets reach their intended recipients and monitoring whether they remain in homes and in good condition over the long-term.
Room for more funding – we believe AMF will be able to use additional funds to deliver additional nets.
Transparency – AMF shares significant information about its work with us and we are able to closely follow and understand its work.

The Against Malaria Foundation

Founders Pledge is a global nonprofit empowering entrepreneurs to do the most good possible with their charitable giving. 

Maximize your philanthropic impact with Founders Pledge. We empower a global community of over 2,100 members, equipping them with everything needed to give effectively: from evidence-led research and expert advice on the world's most pressing problems to comprehensive infrastructure for seamless global grant-making, and a powerful network for collaboration. Together, we've already channeled over $1.5 billion to high-impact causes globally, tackling critical issues like climate change, global health, and emerging existential risks. 

When you donate through every.org today, you're joining this proven movement, and our unique funding model ensures 100% of your contribution goes directly to charity, as our operational costs are generously covered by a dedicated community of philanthropists.

Donate this Giving Season and we'll match your donation up to a value of $750,000, until Dec 31.

Founders Pledge

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.css-1wjgqn{display:inline-block;--textSize:1.5rem;--lineHeight:1.7999999999999998rem;line-height:var(--lineHeight);font-size:var(--textSize);width:100%;}Disease Prevention

New Incentives

Mersal Foundation for Charity and Development

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza - Opera di San Pio da Pietrelcina

Mersal Foundation for Charity and Development

Mersal Foundation for Charity and Development

New Incentives

Disease Prevention