A new initiative to advance forecasting and epistemics for the aim of improving the long term future of humanity.

We research systematic practices to specify and estimate the most important parameters for the most important or scalable decisions. Research areas include forecasting, epistemics, evaluations, ontology, and estimation. We emphasize technological solutions that can heavily scale in the next 5 to 30 years.

We believe that humanity’s success in the next few hundred years will lie intensely on its ability to coordinate and make good decisions. If important governmental and philanthropic bodies become significantly more effective, this will make society far more resilient to many kinds of challenges ahead.

Quantified Uncertainty Research Institute

Prevention, control and treatment of malaria and other communicable diseases  among vulnerable populations.

Our mission is to improve lives in Africa and Asia through sustainable, evidence-based programs  that combat targeted diseases and promote child and maternal health. 

We will accomplish this together with partners and all levels of government, by:

designing and implementing cutting edge research, surveillance and monitoring and evaluation;
selectively scaling up and delivering sustainable evidence-based health programmes;
providing technical assistance and consulting services that shape and strengthen national and international health policies, strategies and systems and build local capacity;
seeking to ensure that our experience, thought leadership, practical findings and research results are effectively communicated and contribute to the coordinated improvement of access to and quality of healthcare. 
Our areas of expertise include: 
disease prevention, diagnosis and treatment
disease control and elimination
health systems strengthening
research, monitoring and evaluation leading to best practice
behavior  change communication
national and international advocacy, and policy development


Malaria Consortium

The Top Charities Fund supports the highest-priority funding needs among our top charities.

We find and recommend outstanding giving opportunities and publish our research to help donors give more effectively and with greater confidence.

All donations here support our Top Charities Fund. Donations to the Top Charities Fund are granted on a rolling basis to support cost-effective funding opportunities at our top charities. We use our latest research to grant the funds to the top charity (or charities) where we believe they’ll do the most good.

Learn more and view past grants at https://www.givewell.org/top-charities-fund


Photo caption: At health centers in Sierra Leone supported by Helen Keller Intl, mothers who bring their children in for twice-yearly vitamin A supplemention can also receive comprehensive counseling about birth control options that are available to them free of charge. Combining family planning and children's healthcare services benefits both mother and child. 2019.

Top Charities Fund

We are a social science think tank researching long-term social and technological change, particularly moral circle expansion. We make our research results public and free, so anyone can use them to make more impactful decisions with their advocacy, careers, donations, and other resources.

We are founded on the principle of effective altruism, meaning we strive to help others as much as possible using the best evidence available. We envision a society in which the interests of all sentient beings are fully considered, regardless of their sex, race, species, substrate, location, or any other characteristic apart from their sentience. We see this expansion as an important means to prevent suffering now and in the far future.

Our mission is to conduct interdisciplinary research on moral circle expansion and to share that research with individuals and institutions making the world a better place. Two particularly important areas of expansion are farmed animals and artificial sentience.

Sentience Institute

StrongMinds provides life-changing mental health services to women in Africa using innovative community-based group therapy.

According to the WHO, depression is the leading cause of disability worldwide, and is a major contributor to the global burden of disease. In Africa, an estimated 66M women have depression and 85% have no access to treatment. Since 2014, StrongMinds has treated over 200,000 individuals for depression symptoms, with 80% measuring as depression-free after therapy. When a woman recovers from depression, she is more engaged in the community and her economic activity increases. Her family eats more meals and her children go to school more often. When you invest in mental health, you invest in the future of an individual, their family, and their community.

StrongMinds Inc

The Centre for Effective Altruism helps to grow and support the effective altruism community.

Effective altruism is about using evidence and reason to figure out how to benefit others as much as possible, and taking action on that basis.

The Centre for Effective Altruism (CEA) is a charity dedicated to building and nurturing a global community of people who are thinking carefully about the world’s biggest problems and taking impactful action to solve them.

We hope that this community can help to build a radically better world: by connecting students and young professionals with relevant experts, we can help them consider their values and find an effective way to contribute that is a good fit for their skills and inclinations.

Centre for Effective Altruism USA

Evidence Action scales evidence-based and cost-effective programs to reduce the burden of poverty. 

Our organization was founded in 2013 to address a big gap in the fight against global poverty--many of the most promising interventions are either implemented at a very small scale, or not at all. We set out to address this gap by building programs that would scale evidence-based and cost-effective interventions, leading to significant improvements in quality of life for hundreds of millions of people. 

Our model worked. In less than a decade, our two flagship programs, the Deworm the World Initiative and Dispensers for Safe Water, have grown to measurably impact over 280 million people each year. This success is achieved through the dedication and talent of our staff, the hard work of our partners, and the commitment of our supporters.

By 2024, we seek to double our impact. We are strengthening and expanding our existing programs, and working to identify a new generation of evidence-based and cost-effective interventions that we can scale to reach millions more. 

We currently operate three programs:

Dispensers for Safe Water 

Dispensers for Safe Water program delivers free and reliable access to safe water for 4 million people in rural Kenya, Uganda, and Malawi.
In rural parts of low-income countries, most water sources are untreated, meaning that water is not safe to drink directly from the source. Our uniquely-engineered chlorine dispensers are installed next to commonly-used water sources, enabling people to treat their water using a safe and pre-measured dose of chlorine. The chlorine stays active for 2-3 days, ensuring water doesn’t get recontaminated even when stored at home. Adding diluted chlorine to water is a WHO-endorsed approach to improving water quality. 
Dispensers for Safe Water is a cost-effective solution - just over $1.00 delivers safe water access to one person for an entire year. In 2019, our program averted over 380,000 cases of diarrhea among children, one of the main causes of childhood mortality in the countries where we operate.

Deworm the World Initiative

Deworm the World Initiative helps governments launch, scale, and sustain school-based deworming programs.

Over 868 million children globally are at risk of contracting parasitic worm infections. If left untreated, infections can lead to anemia, malnourishment, and impaired mental and physical development—ultimately affecting children’s educational outcomes and income as adults.Our program brings free treatment to children at their schools instead of placing the burden on the families to obtain it. We partner with governments to regularly treat all at-risk children in places where at least 20% are infected with worms, as recommended by the World Health Organization.  

Rigorous research shows that deworming leads to significant improvements to children’s health, education, and long-term wellbeing. In 2019, we helped governments treat over 280 million children in India, Kenya, Nigeria, Ethiopia, and Pakistan for less than US 50 cents per treatment.

Accelerator:  
 
Evidence Action Accelerator is our engine for new program development that selects, optimizes, and scales interventions with the highest potential to measurably improve the lives of millions of people in the world’s poorest places.  

Each intervention considered by the Accelerator must undergo a multi-stage process of program development, taking it from an evidence-based concept to a fully-developed solution that can be replicated in multiple geographies. We look for three critical aspects during the assessment process: rigorous evidence, cost-effectiveness, and potential for scale. 

We are currently accelerating two promising health solutions: working with the Liberian government to detect and treat maternal syphilis, with the aim of preventing thousands of child deaths and disabilities each year; and supporting the Indian government to improve the distribution of iron and folic acid supplementation to millions of children and adolescents —treating iron deficiency anemia, one of the main causes of disability in the country.





Evidence Action

FLI catalyzes and supports research and initiatives for safeguarding life and developing optimistic visions of the future.

To catalyze and support research and initiatives for safeguarding life and developing optimistic visions of the future, including positive ways for humanity to steer its own course considering new technologies and challenges.

Future of Life Institute

Learning how to give as effectively as we can and sharing our findings openly so that anyone can build on our work.

Open Philanthropy identifies outstanding giving opportunities, makes grants, follows the results, and publishes our findings. Our main funders are Cari Tuna and Dustin Moskovitz, a co-founder of Facebook and Asana.

We also partner with other donors. We’re passionate about learning and maximizing our impact and excited to connect with others who share these passions.

Prior to becoming an independent organization in June 2017, Open Philanthropy was operated as a partnership between Cari and Dustin's foundation, Good Ventures, and GiveWell.

Open Philanthropy Project

Animal Charity Evaluators helps people help the most animals.

Animal Charity Evaluators (ACE) is a 501(c)(3) nonprofit registered in the United States with a globally distributed team dedicated to impactful animal advocacy. Our mission is to find and promote the most effective ways to help animals. We work toward that mission by evaluating charities, sharing our findings, awarding grants to organizations and promising projects, and fundraising for our recommended charities and grantees. Our organization opposes all systems of oppression and recognizes that they are connected and mutually reinforcing. Ultimately, our vision is a world in which no individual is given less than full moral consideration on the basis of any morally irrelevant feature of their identity, including species membership.

ACE is proud to be considered a leader in the effective animal advocacy movement. Our research comparing the different approaches to reducing the suffering of animals has led to rigorously reviewing charities that work to end factory farming and create meaningful change for farmed and wild animals. Through our Recommend Charity Fund, we have raised and distributed $8.1M to our effective recommended charities. Our Movement Grants program has awarded $5.3M to promising animal advocacy projects around the globe. Since we began tracking this metric in 2014, we estimate that ACE has helped to influence nearly $60M within the animal advocacy movement.

Thanks for helping ACE help animals!

Animal Charity Evaluators

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Designer at every.org. Passionate about animals and nature. Taking action so our children can inherit a better world 💚

effective altruism, xrisk, ai safety, longevity research.. 

We need to scale up new effective charities. I have a ton of respect for their approach, especially after hearing that they shut down their No Lean Season after collecting evidence that showed lower impact than hoped-for: https://www.vox.com/future-perfect/2019/6/7/18654620/evidence-action-no-lean-season-givewell