Nuclear weapons are an existential risk to humanity's forward progress. 

Identifying and updating research priorities on a changing landscape is critically important and deserves dedicated expertise and investigation.

NTI designs innovative threat-reduction projects that show governments the way and build momentum and support for action.

We work with presidents and prime ministers, scientists and technicians, educators and students, and people from around the world. We collaborate with partners worldwide. And we use our voice to raise awareness and advocate for creative solutions.

Nuclear Threat Initiative

The Top Charities Fund supports the highest-priority funding needs among our top charities.

We find and recommend outstanding giving opportunities and publish our research to help donors give more effectively and with greater confidence.

All donations here support our Top Charities Fund. Donations to the Top Charities Fund are granted on a rolling basis to support cost-effective funding opportunities at our top charities. We use our latest research to grant the funds to the top charity (or charities) where we believe they’ll do the most good.

Learn more and view past grants at https://www.givewell.org/top-charities-fund


Photo caption: At health centers in Sierra Leone supported by Helen Keller Intl, mothers who bring their children in for twice-yearly vitamin A supplemention can also receive comprehensive counseling about birth control options that are available to them free of charge. Combining family planning and children's healthcare services benefits both mother and child. 2019.

Top Charities Fund

We provide cash incentives for childhood vaccinations. It’s one of the most cost-effective ways known to save lives.


New Incentives’ mission is to save lives in a way that does the **most good per dollar**.
Guided by evidence, we provide cash incentives to increase childhood vaccination rates.

- We [raise awareness](https://www.newincentives.org/blog-posts/awareness-activities) about the benefits of childhood vaccinations.
- We [provide cash incentives](https://www.newincentives.org/blog-posts/a-day-in-the-life-abubakar-aliyu-field-officer) at government clinics after children receive vaccinations.
- We [help improve the vaccine supply chain](https://www.newincentives.org/blog-posts/supporting-government-partners-with-vaccine-supply-efforts) to ensure enough vaccines are available at clinics.

Together, these efforts are proven to double vaccination rates and save lives.
Learn more about the [randomized controlled trial](https://www.newincentives.org/rct-results).

As of March 2024, New Incentives has reached more the 3 million infants in northern Nigeria.

New Incentives

Malaria Consortium

Delivering unconditional cash directly to the world's poorest households via secure mobile transfers. 

Since 2009, GiveDirectly has delivered more than $580 million in unconditional cash transfers to families in need. These one-time cash transfers allow recipients to invest in what they need most and have been shown to improve their earnings, children’s school attendance, health, nutrition, and mental well-being.
 
GiveDirectly uses government data to target villages where most or all residents are living in extreme poverty, defined by the World Bank as earning under $2.15/day. In-country GiveDirectly staff enroll one member of each household in the entire village to receive a one-time transfer of about $1,000 USD sent in two installments using mobile money. Recipients can then withdraw the mobile funds as cash with local agents and use the funds to invest in what they need – whether it’s on starting a business, education, making their home safer/sturdier, healthcare, or livestock.
 
GiveDirectly uses rigorous experimental research (randomized controlled trials) to measure the impact of their unconditional cash programs and answer public policy questions, generating evidence on key design and implementation questions across varied contexts. You can find over 300 studies on the positive impacts of cash transfers in GiveDirectly’s Cash Research Explorer.

GiveDirectly

International nonprofit ending the abuse of animals raised for food.

The mission of The Humane League, why we exist, is to end the abuse of animals raised for food. This sense of purpose drives every action in our unrelenting march forward for animals.

The Humane League

Catalyzing resilient solutions, scaled to meet the climate challenge.

CATF is a nonprofit organization dedicated to reducing atmospheric pollution through research, advocacy, and private sector collaboration.

Clean Air Task Force

The END Fund is the only private philanthropic initiative solely dedicated to ending the most common neglected tropical diseases.

Our Mission: To control and eliminate the most prevalent neglected tropical diseases (NTDs) among the world's most vulnerable communities and people by 2030. 


NTDs are a group of parasitic and bacterial diseases largely prevalent in tropical regions that currently receive little attention on the global health agenda yet have a significant impact hampering the potential of individuals and communities at large. The devastating effects of NTDs include irreversible blindness, severe disfigurement, stunted cognitive and physical development, especially in children, malnutrition, social isolation, and more. NTDs also cause 170,000 deaths per year. Their comprehensive impact on all aspects of daily life means that the presence of NTDs costs affected countries billions of dollars per year in lost productivity, out-of-pocket expenses, and reduced socioeconomic and educational attainment. 

Currently, 1.7b individuals are affected by such diseases. However, the treatments and knowledge required to eliminate these diseases are readily available, with the annual cost of treatment per individual averaging 50 cents per year. Demonstrating the uniquely cost-effective impact of NTD treatment, studies have shown treatment is the single most efficient means of improving children’s school attendance and capacity to learn. A recent report by Deloitte on Nigeria showcases the significant gains affected economies stand to make should NTDs be eliminated, with Nigeria’s economy estimated to receive an $18.9b boost from now until 2030. The report is available to view here - https://www2.deloitte.com/za/en/nigeria/pages/strategy/articles/Ending_The_Neglect.html

The END Fund helps ensure those at risk of NTDs need not experience such preventable suffering but can live healthy and prosperous lives instead. We do so by working in close partnership with stakeholders across the global NTD community to identify and fulfill gaps and needs in NTD funding, design programs, strengthen the capacity of local actors, provide technical support, and assist with monitoring and evaluation, amongst various additional activities. Our work helps children stay healthy and in school, prevents advanced cases that cause disability and restrain individuals' productive potential, and alleviates the disproportionate disease burden faced by women and girls, as well as the economic burden of disease on families. We have distributed more than 1.2b treatments since our founding in 2012, with 118m individuals treated in 2021 alone.

We envision living in a world in which all have the opportunity to achieve their full potential, with these diseases that have plagued humans for millennia confined to history once and for all.

The END Fund

Evidence Action scales evidence-based and cost-effective programs to reduce the burden of poverty. 

Evidence Action was founded in 2013 to address a big gap in the fight against global poverty – many of the most promising interventions are either implemented at a very small scale, or not at all. We set out to address this gap by building programs that would scale evidence-based and cost-effective interventions, leading to significant improvements in quality of life for hundreds of millions of people.

Our model worked. Since then, our interventions have reached more than 530 million people. This success is achieved through the dedication and talent of our staff, the hard work of our partners, and the commitment of our supporters.

Our Accelerator is the engine for our new program development. To find the most cost-effective solutions in the world, we explore untapped opportunities with the greatest potential for impact. Through a rigorous process, we test groundbreaking health and development interventions, selecting those with a proven ability to reduce the burden of poverty at scale. This focus allows us to maximize the impact made for every single dollar invested.

**Programs:**

**Safe Water Now**

We provide sustained safe water access to communities through water treatment – one of the most cost-effective ways to prevent childhood illnesses and death. Safe Water Now programming in Kenya, Uganda, Malawi, and India uses innovative, low-cost approaches like chlorine dispensers and automatic in-line chlorination. With local government and community buy-in, we reach nearly 10 million people with safe water access and have saved the lives of more than 15,000 children under 5 years old. Now, we are scaling in partnership with the Government of India to reach tens of millions more.

**Deworm the World** 

We help improve children's health, education, and long-term wellbeing by treating parasitic worm

infections at schools. In partnership with governments in Kenya, Nigeria, India, and Pakistan, Evidence Action designs, scales, and sustains cost-effective mass deworming programs. Since 2014, Deworm the World has helped governments deliver 2 billion deworming treatments to children, dramatically reducing worm prevalence and collectively increasing economic productivity by an estimated $23 billion USD.

**Equal Vitamin Access**

We combat the leading cause of childhood malnutrition and disability in low- and middle-income countries by helping to deliver essential supplementation. Equal Vitamin Access provides end-to-end support to governments in India and Malawi to address anemia by leveraging our school-based deworming platform to offer iron and folic acid supplementation cost effectively. In 2023 alone, our program reached 35.8 million children with weekly treatments, giving them a

better chance to develop into strong, healthy adults.

**Syphilis-Free Start**

We safeguard the health of pregnant women and their unborn children by enabling access to low-cost syphilis screening and treatment as part of prenatal care. We partner with governments in Liberia, Cameroon, and Zambia to prevent disability, neonatal

mortality, and stillbirths resulting from congenital syphilis. Syphilis-Free Start’s timely detection and treatment prevented 2,300 adverse outcomes such as blindness, neurological issues, and hearing loss between 2021 and 2023, including 1,300 lives saved.



Evidence Action

We search for the charities that save or improve lives the most per dollar.

Our goal is to produce the world's top research on where to give. Free, for everyone.

We recommend a small number of charities that do an incredible amount of good. 

If you would like to donate to our giving funds or individual top charities, please see our projects below. You can donate here or on the Unrestricted Fund page below to make an unrestricted gift to GiveWell to support the full spectrum of our grantmaking and underwrite our ability to continue doing what we do.

GiveWell

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